Jin Yang1, Hongjie Zhang2, Huitao Zhang2, Wubin Wang2, Yanli Liu2, Yanfeng Fan2. 1. Department of Occupational Health, School of Public Health, Shanxi Medical University, Xinjiannan Road 56, 030001, Taiyuan, China. yj750410@163.com. 2. Department of Occupational Health, School of Public Health, Shanxi Medical University, Xinjiannan Road 56, 030001, Taiyuan, China.
Abstract
PURPOSE: Coke oven emissions containing polycyclic aromatic hydrocarbons (PAHs) are predominant toxic constituents of particulate air pollution that have been linked to increased risk of lung cancer. Numerous epidemiological studies have suggested that oxidative DNA damage may play a pivotal role in the carcinogenic mechanism of lung cancer. Little is known about the effect of interaction between PAHs exposure and lifestyle on DNA oxidative damage. METHODS: The study population is composed by coke oven workers (365) and water treatment workers (144), and their urinary levels of four PAH metabolites and 8-hydroxydeoxyguanosine (8-OHdG) were determined. Airborne samples of exposed sites (4) and control sites (3) were collected, and eight carcinogenic PAHs were detected by high-performance liquid chromatography. RESULTS: The median values of the sum of eight carcinogenic PAHs and BaP in exposed sites were significantly higher than control sites (P < 0.01). The study found that the urinary PAH metabolites were significantly elevated in coke oven workers (P < 0.01). Multivariate logistic regression analysis revealed that the risk of high levels of urinary 8-OHdG will increase with increasing age, cigarette consumption, and levels of urinary 1-hydroxypyrene, and P for trend were all <0.05. Smoking can significantly modify the effects of urinary 1-hydroxypyrene on high concentrations urinary 8-OHdG, during co-exposure to both light or heavy smoking and high 1-hydroxypyrene levels (OR 4.28, 95% CI 1.32-13.86 and OR 5.05, 95% CI 1.63-15.67, respectively). CONCLUSIONS: Our findings quantitatively demonstrate that workers exposed to coke oven fumes and smoking will cause more serious DNA oxidative damage.
PURPOSE: Coke oven emissions containing polycyclic aromatic hydrocarbons (PAHs) are predominant toxic constituents of particulate air pollution that have been linked to increased risk of lung cancer. Numerous epidemiological studies have suggested that oxidative DNA damage may play a pivotal role in the carcinogenic mechanism of lung cancer. Little is known about the effect of interaction between PAHs exposure and lifestyle on DNA oxidative damage. METHODS: The study population is composed by coke oven workers (365) and water treatment workers (144), and their urinary levels of four PAH metabolites and 8-hydroxydeoxyguanosine (8-OHdG) were determined. Airborne samples of exposed sites (4) and control sites (3) were collected, and eight carcinogenic PAHs were detected by high-performance liquid chromatography. RESULTS: The median values of the sum of eight carcinogenic PAHs and BaP in exposed sites were significantly higher than control sites (P < 0.01). The study found that the urinary PAH metabolites were significantly elevated in coke oven workers (P < 0.01). Multivariate logistic regression analysis revealed that the risk of high levels of urinary 8-OHdG will increase with increasing age, cigarette consumption, and levels of urinary 1-hydroxypyrene, and P for trend were all <0.05. Smoking can significantly modify the effects of urinary 1-hydroxypyrene on high concentrations urinary 8-OHdG, during co-exposure to both light or heavy smoking and high 1-hydroxypyrene levels (OR 4.28, 95% CI 1.32-13.86 and OR 5.05, 95% CI 1.63-15.67, respectively). CONCLUSIONS: Our findings quantitatively demonstrate that workers exposed to coke oven fumes and smoking will cause more serious DNA oxidative damage.
Authors: Jean-Jacques Sauvain; Ari Setyan; Pascal Wild; Philippe Tacchini; Grégoire Lagger; Ferdinand Storti; Simon Deslarzes; Michel Guillemin; Michel J Rossi; Michael Riediker Journal: J Occup Med Toxicol Date: 2011-05-30 Impact factor: 2.646
Authors: Yanli Liu; Xuejing Li; Bin Zhang; Ye Fu; Aimin Yang; Hongjie Zhang; Huitao Zhang; Yingying Niu; Jisheng Nie; Jin Yang Journal: Environ Health Date: 2019-07-29 Impact factor: 5.984
Authors: Luigi Vimercati; Lucia Bisceglia; Domenica Cavone; Antonio Caputi; Luigi De Maria; Maria Celeste Delfino; Vincenzo Corrado; Giovanni Maria Ferri Journal: Int J Environ Res Public Health Date: 2020-03-25 Impact factor: 3.390