BACKGROUND: Substance use may increase the risk of non-adherence to antipsychotics, resulting in negative outcomes in patients with psychosis. METHOD: We aimed to quantitatively summarize evidence regarding the effect of cannabis use, the most commonly used illicit drug amongst those with psychosis, on adherence to antipsychotic medication. Studies were identified through a systematic database search. Adopting random-effects models, pooled odds ratios (OR) for risk of non-adherence to antipsychotic medications were calculated comparing: cannabis-users at baseline v. non-users at baseline; non users v. continued cannabis users at follow-up; non-users v. former users at follow-up; former users v. current users. RESULTS: Fifteen observational studies (n = 3678) were included. Increased risk of non-adherence was observed for cannabis users compared to non-users (OR 2.46, n = 3055). At follow-up, increased risk of non-adherence was observed for current users compared to non-users (OR 5.79, n = 175) and former users (OR 5.5, n = 192), while there was no difference between former users and non-users (OR 1.12, n = 187). CONCLUSIONS: Cannabis use increases the risk of non-adherence and quitting cannabis use may help adherence to antipsychotics. Thus, cannabis use may represent a potential target for intervention to improve medication adherence in those with psychosis.
BACKGROUND: Substance use may increase the risk of non-adherence to antipsychotics, resulting in negative outcomes in patients with psychosis. METHOD: We aimed to quantitatively summarize evidence regarding the effect of cannabis use, the most commonly used illicit drug amongst those with psychosis, on adherence to antipsychotic medication. Studies were identified through a systematic database search. Adopting random-effects models, pooled odds ratios (OR) for risk of non-adherence to antipsychotic medications were calculated comparing: cannabis-users at baseline v. non-users at baseline; non users v. continued cannabis users at follow-up; non-users v. former users at follow-up; former users v. current users. RESULTS: Fifteen observational studies (n = 3678) were included. Increased risk of non-adherence was observed for cannabis users compared to non-users (OR 2.46, n = 3055). At follow-up, increased risk of non-adherence was observed for current users compared to non-users (OR 5.79, n = 175) and former users (OR 5.5, n = 192), while there was no difference between former users and non-users (OR 1.12, n = 187). CONCLUSIONS: Cannabis use increases the risk of non-adherence and quitting cannabis use may help adherence to antipsychotics. Thus, cannabis use may represent a potential target for intervention to improve medication adherence in those with psychosis.
Authors: Itxaso González-Ortega; Enrique Echeburúa; Susana Alberich; Miguel Bernardo; Eduard Vieta; Gonzalo Salazar de Pablo; Ana González-Pinto Journal: Int J Environ Res Public Health Date: 2022-06-15 Impact factor: 4.614
Authors: Nestor Szerman; Ignacio Basurte-Villamor; Pablo Vega; Jose Martinez-Raga; Carlos Parro-Torres; Julia Cambra Almerge; Lara Grau-López; Mario De Matteis; Francisco Arias Journal: Drugs Real World Outcomes Date: 2020-03
Authors: Priyanthi B Gjerde; Synne W Steen; Trude S J Vedal; Nils Eiel Steen; Elina J Reponen; Ole A Andreassen; Vidar M Steen; Ingrid Melle Journal: Front Psychiatry Date: 2022-03-29 Impact factor: 4.157
Authors: Peta-Gaye L Thomas-Brown; Jacqueline S Martin; Clayton A Sewell; Wendel D Abel; Maxine D Gossell-Williams Journal: Front Pharmacol Date: 2018-07-18 Impact factor: 5.810