Haruto Uchino1, Jae-Hoon Kim2, Noriyuki Fujima3, Ken Kazumata1, Masaki Ito1, Naoki Nakayama1, Satoshi Kuroda4, Kiyohiro Houkin1. 1. Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. 2. Department of Neurosurgery, Eulji University Eulji Hospi-tal, Seoul, South Korea. 3. Radio-logy, Hokkaido University Graduate School of Medicine, Sapporo, Japan. 4. De-partment of Neurosurgery, University of Toyama, Toyama, Japan.
Abstract
Background: Whether additional indirect bypasses effectively contribute to revascularization in combined procedures remains unclear in patients with moyamoya disease. Objective: To evaluate the longitudinal changes associated with combined procedures while following up pediatric and adult patients long term and to assess whether any other clinical factors or hemodynamic parameters affected these changes to determine an optimal surgical strategy. Methods: We studied 58 hemispheres in 43 adults and 39 hemispheres in 26 children who underwent combined revascularization for moyamoya disease. To evaluate bypass development, we assessed the sizes of the superficial temporal artery and middle meningeal artery using magnetic resonance angiography. Multivariate analysis determined the effects of multiple variables on bypass development. Results: Indirect bypass (middle meningeal artery) development occurred in 95% and 78% of the pediatric and adult hemispheres, respectively. Of these, dual development of direct and indirect bypasses occurred in 54% of the pediatric hemispheres and in 47% of the adult hemispheres. Reciprocal superficial temporal artery regression occurred in 28% of the hemispheres during the transition from the postoperative acute phase to the chronic phase during indirect bypass development. Good indirect bypass development was associated with adult hemispheres at Suzuki stage 4 or greater (odds ratio, 7.4; 95% confidence interval, 1.4-39.4; P = .02). Disease onset type and preoperative hemodynamic parameters were not considered predictors for the development of surgical revascularization. Conclusion: Simultaneous direct and indirect bypass development was most frequently observed, regardless of patient age and hemodynamic status. Applying indirect bypass as an adjunct to direct bypass could maximize revascularization in adults and children.
Background: Whether additional indirect bypasses effectively contribute to revascularization in combined procedures remains unclear in patients with moyamoya disease. Objective: To evaluate the longitudinal changes associated with combined procedures while following up pediatric and adult patients long term and to assess whether any other clinical factors or hemodynamic parameters affected these changes to determine an optimal surgical strategy. Methods: We studied 58 hemispheres in 43 adults and 39 hemispheres in 26 children who underwent combined revascularization for moyamoya disease. To evaluate bypass development, we assessed the sizes of the superficial temporal artery and middle meningeal artery using magnetic resonance angiography. Multivariate analysis determined the effects of multiple variables on bypass development. Results: Indirect bypass (middle meningeal artery) development occurred in 95% and 78% of the pediatric and adult hemispheres, respectively. Of these, dual development of direct and indirect bypasses occurred in 54% of the pediatric hemispheres and in 47% of the adult hemispheres. Reciprocal superficial temporal artery regression occurred in 28% of the hemispheres during the transition from the postoperative acute phase to the chronic phase during indirect bypass development. Good indirect bypass development was associated with adult hemispheres at Suzuki stage 4 or greater (odds ratio, 7.4; 95% confidence interval, 1.4-39.4; P = .02). Disease onset type and preoperative hemodynamic parameters were not considered predictors for the development of surgical revascularization. Conclusion: Simultaneous direct and indirect bypass development was most frequently observed, regardless of patient age and hemodynamic status. Applying indirect bypass as an adjunct to direct bypass could maximize revascularization in adults and children.
Authors: Ramin A Morshed; Adib A Abla; Daniel Murph; Jasmin M Dao; Ethan A Winkler; Jan-Karl Burkhardt; Kathleen Colao; Steven W Hetts; Heather J Fullerton; Michael T Lawton; Nalin Gupta; Christine K Fox Journal: J Clin Neurosci Date: 2020-08-19 Impact factor: 1.961
Authors: Vincent N Nguyen; Kara A Parikh; Mustafa Motiwala; L Erin Miller; Michael Barats; Camille Milton; Nickalus R Khan Journal: Front Surg Date: 2022-08-19