| Literature DB >> 28168833 |
Tim Ripperger1, Stefan S Bielack2, Arndt Borkhardt3, Ines B Brecht4,5, Birgit Burkhardt6, Gabriele Calaminus6, Klaus-Michael Debatin7, Hedwig Deubzer8, Uta Dirksen6, Cornelia Eckert8, Angelika Eggert8, Miriam Erlacher9, Gudrun Fleischhack10, Michael C Frühwald11, Astrid Gnekow11, Gudrun Goehring1, Norbert Graf12, Helmut Hanenberg3,13, Julia Hauer3, Barbara Hero14, Simone Hettmer9, Katja von Hoff15, Martin Horstmann15, Juliane Hoyer16, Thomas Illig1,17, Peter Kaatsch18, Roland Kappler19, Kornelius Kerl6, Thomas Klingebiel20, Udo Kontny21, Uwe Kordes15, Dieter Körholz22, Ewa Koscielniak2, Christof M Kramm23, Michaela Kuhlen3, Andreas E Kulozik24, Britta Lamottke25, Ivo Leuschner26, Dietmar R Lohmann27,28, Andrea Meinhardt22, Markus Metzler5, Lüder H Meyer7, Olga Moser21, Michaela Nathrath29,30,31, Charlotte M Niemeyer9, Rainer Nustede32, Kristian W Pajtler24,33, Claudia Paret34, Mareike Rasche10, Dirk Reinhardt10, Olaf Rieß35, Alexandra Russo34, Stefan Rutkowski15, Brigitte Schlegelberger1, Dominik Schneider36, Reinhard Schneppenheim15, Martin Schrappe37, Christopher Schroeder35, Dietrich von Schweinitz19, Thorsten Simon14, Monika Sparber-Sauer2, Claudia Spix18, Martin Stanulla25, Doris Steinemann1, Brigitte Strahm9, Petra Temming10,28, Kathrin Thomay1, Andre O von Bueren38,39, Peter Vorwerk40, Olaf Witt24, Marcin Wlodarski9, Willy Wössmann22, Martin Zenker41, Stefanie Zimmermann20, Stefan M Pfister24,33, Christian P Kratz25.
Abstract
Heritable predisposition is an important cause of cancer in children and adolescents. Although a large number of cancer predisposition genes and their associated syndromes and malignancies have already been described, it appears likely that there are more pediatric cancer patients in whom heritable cancer predisposition syndromes have yet to be recognized. In a consensus meeting in the beginning of 2016, we convened experts in Human Genetics and Pediatric Hematology/Oncology to review the available data, to categorize the large amount of information, and to develop recommendations regarding when a cancer predisposition syndrome should be suspected in a young oncology patient. This review summarizes the current knowledge of cancer predisposition syndromes in pediatric oncology and provides essential information on clinical situations in which a childhood cancer predisposition syndrome should be suspected.Entities:
Keywords: genetic cancer predisposition; genetic predisposition testing; genetic screening; germline mutation; hereditary cancer syndrome
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Year: 2017 PMID： 28168833 DOI： 10.1002/ajmg.a.38142
Source DB: PubMed Journal: Am J Med Genet A ISSN： 1552-4825 Impact factor: 2.802