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Literature DB >> 28168600

The role of pancreatic cancer-derived exosomes in cancer progress and their potential application as biomarkers.

Abstract

Pancreatic cancer is one of the most deadly cancers, with dismal prognosis due to its poor early detection rate and high metastatic rate. Thus, elucidation of the molecular mechanisms accounting for its metastasis and discovery of competent biomarkers is required. Exosomes are multivesicular body-derived small extracellular vesicles released by various cell types that serve as important message carriers during intercellular communication. They are also known to play critical roles during cancer-genesis, cancer-related immune reactions, and metastasis. They also possess promising potential as novel biomarkers for cancer early detection. Therefore, extensive studies on pancreatic cancer-derived exosomes are currently being performed because they hold the promising potential of elevating the overall survival rate of patients with pancreatic cancer. In the present review, we focus on the role of exosomes in pancreatic cancer-related immune reactions, metastasis, and complications, and on their potential application as pancreatic cancer biomarkers.

Entities: Disease Species

Keywords: Cancer biomarker; Exosomes; Immunology; Metastasis; Pancreatic cancer

Mesh：

Substances：
Biomarkers, Tumor

Year: 2017 PMID： 28168600 DOI： 10.1007/s12094-017-1625-2

Source DB: PubMed Journal: Clin Transl Oncol ISSN： 1699-048X Impact factor: 3.405

94 in total

1. ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming.

Authors: Elodie Segura; Carole Nicco; Bérangère Lombard; Philippe Véron; Graça Raposo; Frédéric Batteux; Sebastian Amigorena; Clotilde Théry
Journal: Blood Date: 2005-03-24 Impact factor: 22.113

2. Pancreatic cancer derived exosomes regulate the expression of TLR4 in dendritic cells via miR-203.

Authors: Min Zhou; Jionghuang Chen; Liangjing Zhou; Wenchao Chen; Guoping Ding; Liping Cao
Journal: Cell Immunol Date: 2014-09-28 Impact factor: 4.868

3. Pancreatic Cancer-Derived Exosomes Cause Paraneoplastic β-cell Dysfunction.

Authors: Naureen Javeed; Gunisha Sagar; Shamit K Dutta; Thomas C Smyrk; Julie S Lau; Santanu Bhattacharya; Mark Truty; Gloria M Petersen; Randal J Kaufman; Suresh T Chari; Debabrata Mukhopadhyay
Journal: Clin Cancer Res Date: 2014-10-29 Impact factor: 12.531

4. Identification of pancreatic cancer stem cells.

Authors: Chenwei Li; David G Heidt; Piero Dalerba; Charles F Burant; Lanjing Zhang; Volkan Adsay; Max Wicha; Michael F Clarke; Diane M Simeone
Journal: Cancer Res Date: 2007-02-01 Impact factor: 12.701

5. Tspan8, CD44v6 and alpha6beta4 are biomarkers of migrating pancreatic cancer-initiating cells.

Authors: Haobin Wang; Sanyukta Rana; Nathalia Giese; Markus W Büchler; Margot Zöller
Journal: Int J Cancer Date: 2013-02-15 Impact factor: 7.396

6. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis.

Authors: Weiying Zhou; Miranda Y Fong; Yongfen Min; George Somlo; Liang Liu; Melanie R Palomares; Yang Yu; Amy Chow; Sean Timothy Francis O'Connor; Andrew R Chin; Yun Yen; Yafan Wang; Eric G Marcusson; Peiguo Chu; Jun Wu; Xiwei Wu; Arthur Xuejun Li; Zhuo Li; Hanlin Gao; Xiubao Ren; Mark P Boldin; Pengnian Charles Lin; Shizhen Emily Wang
Journal: Cancer Cell Date: 2014-04-14 Impact factor: 31.743

7. Standardization of sample collection, isolation and analysis methods in extracellular vesicle research.

Authors: Kenneth W Witwer; Edit I Buzás; Lynne T Bemis; Adriana Bora; Cecilia Lässer; Jan Lötvall; Esther N Nolte-'t Hoen; Melissa G Piper; Sarada Sivaraman; Johan Skog; Clotilde Théry; Marca H Wauben; Fred Hochberg
Journal: J Extracell Vesicles Date: 2013-05-27

8. Minimally invasive genomic and transcriptomic profiling of visceral cancers by next-generation sequencing of circulating exosomes.

Authors: F A San Lucas; K Allenson; V Bernard; J Castillo; D U Kim; K Ellis; E A Ehli; G E Davies; J L Petersen; D Li; R Wolff; M Katz; G Varadhachary; I Wistuba; A Maitra; H Alvarez
Journal: Ann Oncol Date: 2015-12-17 Impact factor: 32.976

Review 9. Extracellular vesicles: emerging targets for cancer therapy.

Authors: Pieter Vader; Xandra O Breakefield; Matthew J A Wood
Journal: Trends Mol Med Date: 2014-04-03 Impact factor: 11.951

10. Label-Free Nanoplasmonic-Based Short Noncoding RNA Sensing at Attomolar Concentrations Allows for Quantitative and Highly Specific Assay of MicroRNA-10b in Biological Fluids and Circulating Exosomes.

Authors: Gayatri K Joshi; Samantha Deitz-McElyea; Thakshila Liyanage; Katie Lawrence; Sonali Mali; Rajesh Sardar; Murray Korc
Journal: ACS Nano Date: 2015-10-07 Impact factor: 15.881

17 in total

1. Label-free characterization of exosome via surface enhanced Raman spectroscopy for the early detection of pancreatic cancer.

Authors: Joseph Carmicheal; Chihiro Hayashi; Xi Huang; Lei Liu; Yao Lu; Alexey Krasnoslobodtsev; Alexander Lushnikov; Prakash G Kshirsagar; Asish Patel; Maneesh Jain; Yuri L Lyubchenko; Yongfeng Lu; Surinder K Batra; Sukhwinder Kaur
Journal: Nanomedicine Date: 2018-12-11 Impact factor: 5.307

Review 2. Extracellular vesicles as mediators of the progression and chemoresistance of pancreatic cancer and their potential clinical applications.

Authors: Jiangdong Qiu; Gang Yang; Mengyu Feng; Suli Zheng; Zhe Cao; Lei You; Lianfang Zheng; Taiping Zhang; Yupei Zhao
Journal: Mol Cancer Date: 2018-01-05 Impact factor: 27.401

3. Integrated whole genome microarray analysis and immunohistochemical assay identifies COL11A1, GJB2 and CTRL as predictive biomarkers for pancreatic cancer.

Authors: Defeng Sun; Haoyi Jin; Jun Zhang; Xiaodong Tan
Journal: Cancer Cell Int Date: 2018-11-06 Impact factor: 5.722

4. Overexpression of PIK3R1 promotes hepatocellular carcinoma progression.

Authors: Xuejun Ai; Lei Xiang; Zhi Huang; Shi Zhou; Shuai Zhang; Tao Zhang; Tianpeng Jiang
Journal: Biol Res Date: 2018-11-29 Impact factor: 5.612

Review 5. Emerging role of exosome signalling in maintaining cancer stem cell dynamic equilibrium.

Authors: Zhen Sun; Li Wang; Lihua Dong; Xiujie Wang
Journal: J Cell Mol Med Date: 2018-05-25 Impact factor: 5.295

Review 6. Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization.

Authors: Franco Cortese; Dmitry Klokov; Andreyan Osipov; Jakub Stefaniak; Alexey Moskalev; Jane Schastnaya; Charles Cantor; Alexander Aliper; Polina Mamoshina; Igor Ushakov; Alex Sapetsky; Quentin Vanhaelen; Irina Alchinova; Mikhail Karganov; Olga Kovalchuk; Ruth Wilkins; Andrey Shtemberg; Marjan Moreels; Sarah Baatout; Evgeny Izumchenko; João Pedro de Magalhães; Artem V Artemov; Sylvain V Costes; Afshin Beheshti; Xiao Wen Mao; Michael J Pecaut; Dmitry Kaminskiy; Ivan V Ozerov; Morten Scheibye-Knudsen; Alex Zhavoronkov
Journal: Oncotarget Date: 2018-02-12