| Literature DB >> 28166215 |
Brian D Hobbs1,2, Kim de Jong3,4, Maxime Lamontagne5, Yohan Bossé5,6, Nick Shrine7, María Soler Artigas7, Louise V Wain7, Ian P Hall8, Victoria E Jackson7, Annah B Wyss9, Stephanie J London9, Kari E North10, Nora Franceschini10, David P Strachan11, Terri H Beaty12, John E Hokanson13, James D Crapo14, Peter J Castaldi1,15, Robert P Chase1, Traci M Bartz16,17,18, Susan R Heckbert16,19,20, Bruce M Psaty16,17,19,20,21, Sina A Gharib22, Pieter Zanen23, Jan W Lammers23, Matthijs Oudkerk24, H J Groen25, Nicholas Locantore26, Ruth Tal-Singer26, Stephen I Rennard27,28, Jørgen Vestbo29, Wim Timens30, Peter D Paré31, Jeanne C Latourelle32, Josée Dupuis33,34, George T O'Connor34,35, Jemma B Wilk34, Woo Jin Kim36, Mi Kyeong Lee36, Yeon-Mok Oh37, Judith M Vonk3,4, Harry J de Koning38, Shuguang Leng39, Steven A Belinsky39, Yohannes Tesfaigzi39, Ani Manichaikul40,41, Xin-Qun Wang41, Stephen S Rich40,41, R Graham Barr42, David Sparrow43, Augusto A Litonjua1,2, Per Bakke44, Amund Gulsvik44, Lies Lahousse45,46, Guy G Brusselle45,46,47, Bruno H Stricker45,48,49,50, André G Uitterlinden45,49,50, Elizabeth J Ampleford51, Eugene R Bleecker51, Prescott G Woodruff52, Deborah A Meyers51, Dandi Qiao1, David A Lomas53, Jae-Joon Yim54, Deog Kyeom Kim55, Iwona Hawrylkiewicz56, Pawel Sliwinski56, Megan Hardin1,2,28, Tasha E Fingerlin57,58, David A Schwartz57,59,60, Dirkje S Postma4,25, William MacNee61, Martin D Tobin7,62, Edwin K Silverman1,2, H Marike Boezen3,4, Michael H Cho1,2.
Abstract
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10-6) in 9,498 cases and 9,748 controls. In the combined meta-analysis, we identified 22 loci associated at genome-wide significance, including 13 new associations with COPD. Nine of these 13 loci have been associated with lung function in general population samples, while 4 (EEFSEC, DSP, MTCL1, and SFTPD) are new. We noted two loci shared with pulmonary fibrosis (FAM13A and DSP) but that had opposite risk alleles for COPD. None of our loci overlapped with genome-wide associations for asthma, although one locus has been implicated in joint susceptibility to asthma and obesity. We also identified genetic correlation between COPD and asthma. Our findings highlight new loci associated with COPD, demonstrate the importance of specific loci associated with lung function to COPD, and identify potential regions of genetic overlap between COPD and other respiratory diseases.Entities:
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Year: 2017 PMID： 28166215 PMCID： PMC5381275 DOI： 10.1038/ng.3752
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330