| Literature DB >> 28165740 |
Chung Sub Kim1, Munhyung Bae2, Joonseok Oh3,4, Lalita Subedi5,6, Won Se Suh1, Sang Zin Choi7, Mi Won Son7, Sun Yeou Kim5,6, Sang Un Choi8, Dong-Chan Oh2, Kang Ro Lee1.
Abstract
Four biflavonoid glycosides, balsamisides A-D (1-4), and nine known compounds (5-13) were obtained from the white petals of Impatiens balsamina. The 2D structures of the purified phytochemicals were established using conventional NMR techniques in addition to the new long-range HSQMBC NMR experiment. Acid hydrolysis followed by experimental and quantum-mechanics-based ECD data analysis permitted full configurational assignment of the purified metabolites. Compounds 1-13 were assessed for their potential to impede the generation of nitric oxide in lipopolysaccharide-stimulated BV2 cells. They were also investigated for potential neuroprotective activity using C6 cells and cytotoxicity against some human tumor cell lines, but were inactive (IC50 > 10 μM) against all the cell lines.Entities:
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Year: 2017 PMID： 28165740 DOI： 10.1021/acs.jnatprod.6b00981
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050