Literature DB >> 28165637

Neuroprotective effects of extracellular DJ-1 on reperfusion injury in SH-SY5Y cells.

Jay Han1, Beryl Luk1, Frank J S Lee1.   

Abstract

Using an in vitro model of ischemic stroke we treated differentiated SH-SY5Y cells to oxygen-glucose deprivation (OGD) followed by a reperfusion period where normal growth conditions were restored. Cells undergoing OGD exhibited significant cell death as measure by propidium iodide staining. However, cells treated with exogenous extracellular DJ-1 during reperfusion exhibited significant rescue from OGD-induced cell death.
© 2017 Wiley Periodicals, Inc.

Entities:  

Keywords:  OGD; PARK7; cell death; hypoxia

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Year:  2017        PMID： 28165637     DOI： 10.1002/syn.21963

Source DB:  PubMed          Journal:  Synapse        ISSN： 0887-4476            Impact factor:   2.562


  3 in total

1.  DJ-1 interacts with the ectopic ATP-synthase in endothelial cells during acute ischemia and reperfusion.

Authors:  Alex Gallinat; Lina Badimon
Journal:  Sci Rep       Date:  2022-07-26       Impact factor: 4.996

2.  DJ-1 administration exerts cardioprotection in a mouse model of acute myocardial infarction.

Authors:  Alex Gallinat; Guiomar Mendieta; Gemma Vilahur; Teresa Padró; Lina Badimon
Journal:  Front Pharmacol       Date:  2022-09-23       Impact factor: 5.988

3.  Neuroprotective effects of human amniotic fluid stem cells-derived secretome in an ischemia/reperfusion model.

Authors:  Vanessa Castelli; Ivana Antonucci; Michele d'Angelo; Alessandra Tessitore; Veronica Zelli; Elisabetta Benedetti; Claudio Ferri; Giovambattista Desideri; Cesar Borlongan; Liborio Stuppia; Annamaria Cimini
Journal:  Stem Cells Transl Med       Date:  2020-10-07       Impact factor: 6.940
  3 in total

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