BACKGROUND: Antiretroviral therapy (ART) in HIV pregnant women has led to a dramatic decrease in the rate of HIV mother-to-child transmission but this benefit is counterbalanced with adverse effects related to in utero and neonatal exposure to ART. In 2013, some parents described neurodevelopmental disorders in their children. METHODS: A standardized letter was sent to the 133 women who delivered in Nantes hospital from 01/01/2003 to 31/12/2012 (167 births). RESULTS: Response rate was 33%. Over a 10-year period, 7 children had behavioral disorders and/or cognitive/developmental delay, 1 child had developmental delay + growth retardation and 2 experienced cancer. CONCLUSIONS: We found a significant association between neurodevelopmental disorders, preterm birth and exposure to 3 nucleoside reverse transcriptase inhibitors (NRTIs). Further studies are needed and long-term follow-up into adulthood should continue.
BACKGROUND: Antiretroviral therapy (ART) in HIV pregnant women has led to a dramatic decrease in the rate of HIV mother-to-child transmission but this benefit is counterbalanced with adverse effects related to in utero and neonatal exposure to ART. In 2013, some parents described neurodevelopmental disorders in their children. METHODS: A standardized letter was sent to the 133 women who delivered in Nantes hospital from 01/01/2003 to 31/12/2012 (167 births). RESULTS: Response rate was 33%. Over a 10-year period, 7 children had behavioral disorders and/or cognitive/developmental delay, 1 child had developmental delay + growth retardation and 2 experienced cancer. CONCLUSIONS: We found a significant association between neurodevelopmental disorders, preterm birth and exposure to 3 nucleoside reverse transcriptase inhibitors (NRTIs). Further studies are needed and long-term follow-up into adulthood should continue.
Authors: Ariane Alimenti; John C Forbes; Tim F Oberlander; Deborah M Money; Ruth E Grunau; Michael P Papsdorf; Evelyn Maan; Lesley J Cole; David R Burdge Journal: Pediatrics Date: 2006-08-28 Impact factor: 7.124
Authors: Sarah K Himes; Yanling Huo; George K Siberry; Paige L Williams; Mabel L Rice; Patricia A Sirois; Toni Frederick; Rohan Hazra; Marilyn A Huestis Journal: J Acquir Immune Defic Syndr Date: 2015-06-01 Impact factor: 3.731
Authors: Antoni Noguera; Claudia Fortuny; Carmen Muñoz-Almagro; Emilia Sanchez; M Antonia Vilaseca; Rafael Artuch; Jordi Pou; Rafael Jimenez Journal: Pediatrics Date: 2004-10-18 Impact factor: 7.124
Authors: Paige L Williams; Miguel Marino; Kathleen Malee; Susan Brogly; Michael D Hughes; Lynne M Mofenson Journal: Pediatrics Date: 2010-01-18 Impact factor: 7.124
Authors: Patricia A Sirois; Yanling Huo; Paige L Williams; Kathleen Malee; Patricia A Garvie; Betsy Kammerer; Kenneth Rich; Russell B Van Dyke; Molly L Nozyce Journal: Pediatr Infect Dis J Date: 2013-06 Impact factor: 2.129
Authors: J Zeitlin; K Szamotulska; N Drewniak; A D Mohangoo; J Chalmers; L Sakkeus; L Irgens; M Gatt; M Gissler; B Blondel Journal: BJOG Date: 2013-05-24 Impact factor: 6.531