Literature DB >> 2816360

Growth hormone treatment in adults with growth hormone deficiency: effect on muscle fibre size and proportions.

H M Whitehead1, J S Gilliland, I V Allen, D R Hadden.   

Abstract

The effect of a 6-month period of substitution therapy with recombinant human growth hormone (rhGH) on muscle fibre size and muscle fibre type proportions has been investigated in a group of 13 adults with growth hormone deficiency. All had a peak growth hormone (GH) response to insulin-induced hypoglycaemia of less than 7 mU/l. There was no statistically significant change in the lesser fibre diameter or fibre proportions of either type 1 or type 2 muscle fibres in the rhGH group, as compared with placebo.

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Year:  1989        PMID: 2816360     DOI: 10.1111/j.1651-2227.1989.tb11246.x

Source DB:  PubMed          Journal:  Acta Paediatr Scand Suppl        ISSN: 0300-8843


  6 in total

Review 1.  Effects of GH replacement on metabolism and physical performance in GH deficient adults.

Authors:  S K Abdul Shakoor; S M Shalet
Journal:  J Endocrinol Invest       Date:  2003-09       Impact factor: 4.256

Review 2.  Optimum use of growth hormone in children.

Authors:  Z Laron; O Butenandt
Journal:  Drugs       Date:  1991-07       Impact factor: 9.546

Review 3.  Musculoskeletal Effects of Altered GH Action.

Authors:  Jonathan A Young; Shouan Zhu; Edward O List; Silvana Duran-Ortiz; Yosri Slama; Darlene E Berryman
Journal:  Front Physiol       Date:  2022-05-19       Impact factor: 4.755

4.  Growth hormone substitution titrated to obtain IGF-I levels in the physiological range in hypopituitary adults: effects upon dynamic strength, endurance and EMG.

Authors:  Bertil Ekman; Björn Gerdle; Hans J Arnqvist
Journal:  Eur J Appl Physiol       Date:  2003-07-26       Impact factor: 3.078

Review 5.  Growth hormone replacement therapy for growth hormone-deficient adults.

Authors:  J Powrie; A Weissberger; P Sönksen
Journal:  Drugs       Date:  1995-05       Impact factor: 9.546

Review 6.  Effects of growth hormone on body composition and bone metabolism.

Authors:  A L Carrel; D B Allen
Journal:  Endocrine       Date:  2000-04       Impact factor: 3.925

  6 in total

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