Ruzica Z Conic1, Karl Napekoski2, Heidi Schuetz3, Melissa Piliang3, Wilma Bergfeld3, Natasha Atanaskova Mesinkovska4. 1. Department of Dermatology and Dermatopathology, Cleveland Clinic, Cleveland, Ohio; Department of Dermatology, Case Western Reserve University, Cleveland, Ohio. Electronic address: ruzica.conic@gmail.com. 2. Department of Pathology, Edward Hospital, Naperville, Illinois. 3. Department of Dermatology and Dermatopathology, Cleveland Clinic, Cleveland, Ohio. 4. Department of Dermatology and Dermatopathology, Cleveland Clinic, Cleveland, Ohio; Department of Dermatology and Dermatopathology, University of California Irvine, Irvine, California.
Abstract
BACKGROUND: Seborrheic keratoses (SK) are common skin neoplasms considered to be benign. Reports of associated squamous cell carcinoma arising within seborrheic keratosis (SCC-SK) have been described. OBJECTIVE: To describe the histopathologic characteristics of SCC-SK and identify predisposing factors in formation of these rare lesions. METHODS: There were 162 cases of SCC-SK in a span of a decade (2003-2014). All of the histopathologic specimens and medical records were reviewed. Data from these patients were compared to a control group with seborrheic keratosis who were matched by age, sex, and location of lesion from the same time period (n = 162). RESULTS: SCC-SK has the classic histopathologic features of SK, such as hyperkeratosis, parakeratosis, papillomatosis, and pseudohorn cysts. The areas of squamous cell carcinoma were characterized by areas of squamous dysplasia (100%), hypogranulosis (79.6%), squamous eddies (79.6%), solar elastosis (80.9%), and brown pigmentation (59.9%). Patients with a history of immunosuppression had an increased risk for developing SCC-SK (19% vs 3%; P < .01), particularly when inhibition was transplant-associated (10% vs 0%; P < .01). LIMITATIONS: This was a single center, retrospective study. CONCLUSION: SCC-SK occurs more often in elderly men with a history of immunosuppression associated with organ transplants.
BACKGROUND:Seborrheic keratoses (SK) are common skin neoplasms considered to be benign. Reports of associated squamous cell carcinoma arising within seborrheic keratosis (SCC-SK) have been described. OBJECTIVE: To describe the histopathologic characteristics of SCC-SK and identify predisposing factors in formation of these rare lesions. METHODS: There were 162 cases of SCC-SK in a span of a decade (2003-2014). All of the histopathologic specimens and medical records were reviewed. Data from these patients were compared to a control group with seborrheic keratosis who were matched by age, sex, and location of lesion from the same time period (n = 162). RESULTS: SCC-SK has the classic histopathologic features of SK, such as hyperkeratosis, parakeratosis, papillomatosis, and pseudohorn cysts. The areas of squamous cell carcinoma were characterized by areas of squamous dysplasia (100%), hypogranulosis (79.6%), squamous eddies (79.6%), solar elastosis (80.9%), and brown pigmentation (59.9%). Patients with a history of immunosuppression had an increased risk for developing SCC-SK (19% vs 3%; P < .01), particularly when inhibition was transplant-associated (10% vs 0%; P < .01). LIMITATIONS: This was a single center, retrospective study. CONCLUSION: SCC-SK occurs more often in elderly men with a history of immunosuppression associated with organ transplants.
Authors: Lisa M Hillen; Dorit Rennspiess; Ernst-Jan Speel; Anke M Haugg; Véronique Winnepenninckx; Axel Zur Hausen Journal: Front Microbiol Date: 2018-01-09 Impact factor: 5.640