Literature DB >> 28161868

Protective Effect of Resveratrol on the Brain in a Rat Model of Epilepsy.

Zhen Li1,2, Zhuyan You2, Min Li2, Liang Pang2, Juan Cheng1,2, Liecheng Wang3,4.   

Abstract

Accumulating evidence has suggested resveratrol as a promising drug candidate for the treatment of epilepsy. To validate this, we tested the protective effect of resveratrol on a kainic acid (KA)-induced epilepsy model in rats and investigated the underlying mechanism. We found that acute resveratrol application partially inhibited evoked epileptiform discharges in the hippocampal CA1 region. During acute, silent and chronic phases of epilepsy, the expression of hippocampal kainate glutamate receptor (GluK2) and the GABAA receptor alpha1 subunit (GABAAR-alpha1) was up-regulated and down-regulated, respectively. Resveratrol reversed these effects and induced an antiepileptic effect. Furthermore, in the chronic phase, resveratrol treatment inhibited the KA-induced increased glutamate/GABA ratio in the hippocampus. The antiepileptic effects of resveratrol may be partially attributed to the reduction of glutamate-induced excitotoxicity and the enhancement in GABAergic inhibition.

Entities:  

Keywords:  Epilepsy; GABA; Glutamate; Hippocampus; Resveratrol

Mesh：

Substances：

Year:  2017        PMID： 28161868      PMCID： PMC5567521          DOI： 10.1007/s12264-017-0097-2

Source DB:  PubMed          Journal:  Neurosci Bull        ISSN： 1995-8218            Impact factor:   5.203


  40 in total

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2.  Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE).

Authors:  Robert S Fisher; Walter van Emde Boas; Warren Blume; Christian Elger; Pierre Genton; Phillip Lee; Jerome Engel
Journal:  Epilepsia       Date:  2005-04       Impact factor: 5.864

3.  Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice.

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Journal:  Nature       Date:  1998-04-09       Impact factor: 49.962

4.  The synergic effect of regular exercise and resveratrol on kainate-induced oxidative stress and seizure activity in mice.

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Journal:  Neurochem Res       Date:  2012-10-04       Impact factor: 3.996

5.  Excitatory synaptic potentials in kainic acid-denervated rat CA1 pyramidal neurons.

Authors:  D A Turner; H V Wheal
Journal:  J Neurosci       Date:  1991-09       Impact factor: 6.167

6.  Neuroprotective effects of resveratrol on ischemic injury mediated by modulating the release of neurotransmitter and neuromodulator in rats.

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Journal:  Neurosci Lett       Date:  2008-05-07       Impact factor: 3.046

8.  Rapid onset of a kainate-induced mirror focus in rat hippocampus is mediated by contralateral AMPA receptors.

Authors:  Tiwalade Sobayo; David J Mogul
Journal:  Epilepsy Res       Date:  2013-05-10       Impact factor: 3.045

9.  Ih channels control feedback regulation from amacrine cells to photoreceptors.

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10.  Sirtuin activators mimic caloric restriction and delay ageing in metazoans.

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Journal:  Nature       Date:  2004-07-14       Impact factor: 69.504
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  11 in total

1.  Blockade of c-Src Within the Paraventricular Nucleus Attenuates Inflammatory Cytokines and Oxidative Stress in the Mechanism of the TLR4 Signal Pathway in Salt-Induced Hypertension.

Authors:  Qing Yang; Xiao-Jing Yu; Qing Su; Qiu-Yue Yi; Xin-Ai Song; Xiao-Lian Shi; Hong-Bao Li; Jie Qi; Guo-Qing Zhu; Yu-Ming Kang
Journal:  Neurosci Bull       Date:  2019-10-22       Impact factor: 5.203

2.  Chemical Stimulation of Renal Tissue Induces Sympathetic Activation and a Pressor Response via the Paraventricular Nucleus in Rats.

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3.  Blockade of Endogenous Angiotensin-(1-7) in Hypothalamic Paraventricular Nucleus Attenuates High Salt-Induced Sympathoexcitation and Hypertension.

Authors:  Xiao-Jing Yu; Yu-Wang Miao; Hong-Bao Li; Qing Su; Kai-Li Liu; Li-Yan Fu; Yi-Kang Hou; Xiao-Lian Shi; Ying Li; Jian-Jun Mu; Wen-Sheng Chen; Wei Cui; Guo-Qing Zhu; Philip J Ebenezer; Joseph Francis; Yu-Ming Kang
Journal:  Neurosci Bull       Date:  2018-10-16       Impact factor: 5.203

4.  Synchrotron Radiation-Based Three-Dimensional Visualization of Angioarchitectural Remodeling in Hippocampus of Epileptic Rats.

Authors:  Pan Gu; Zi-Hao Xu; Yu-Ze Cao; Sheng-Hui Liao; Qian-Fang Deng; Xian-Zhen Yin; Zhuo-Lu Wang; Zhuo-Hui Chen; Xin-Hang Hu; Hui Wang; Li-Zhi Li; Shi-Xin Liu; Hui Ding; Shu-Peng Shi; Hong-Lei Li; Ti-Qiao Xiao; Bo Xiao; Meng-Qi Zhang
Journal:  Neurosci Bull       Date:  2019-12-10       Impact factor: 5.203

5.  Fluoxetine is Neuroprotective in Early Brain Injury via its Anti-inflammatory and Anti-apoptotic Effects in a Rat Experimental Subarachnoid Hemorrhage Model.

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Journal:  Neurosci Bull       Date:  2018-04-30       Impact factor: 5.203

Review 6.  Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction-Are We There Yet?

Authors:  Olagide W Castro; Dinesh Upadhya; Maheedhar Kodali; Ashok K Shetty
Journal:  Front Neurol       Date:  2017-11-13       Impact factor: 4.003

7.  Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats.

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Journal:  Neurosci Bull       Date:  2018-10-15       Impact factor: 5.203

Review 8.  Adult Neurogenesis in Epileptogenesis: An Update for Preclinical Finding and Potential Clinical Translation.

Authors:  Liying Chen; Yi Wang; Zhong Chen
Journal:  Curr Neuropharmacol       Date:  2020       Impact factor: 7.363

Review 9.  Neuroprotective Polyphenols: A Modulatory Action on Neurotransmitter Pathways.

Authors:  Elzbieta Rebas; Jowita Rzajew; Tomasz Radzik; Ludmila Zylinska
Journal:  Curr Neuropharmacol       Date:  2020       Impact factor: 7.363

10.  Anticonvulsant effect of pterostilbene and its influence on the anxiety- and depression-like behavior in the pentetrazol-kindled mice: behavioral, biochemical, and molecular studies.

Authors:  Dorota Nieoczym; Katarzyna Socała; Agnieszka Zelek-Molik; Mateusz Pieróg; Katarzyna Przejczowska-Pomierny; Małgorzata Szafarz; Elżbieta Wyska; Irena Nalepa; Piotr Wlaź
Journal:  Psychopharmacology (Berl)       Date:  2021-08-01       Impact factor: 4.415
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