Radhika Sridharan1, Mitchell Philip Engle2, Naveen Garg3, Wei Wei4, Behrang Amini5. 1. Department of Diagnostic Imaging, Universiti Kebangsaan Malaysia Medical Centre, JalanYaacob Latif, Cheras, 56000, Kuala Lumpur, Malaysia. 2. Department of Pain Medicine, The University of Texas M.D. Anderson Cancer Center, 1400 Pressler, Unit 0409, Houston, TX, 77030, USA. 3. Department of Diagnostic Imaging, The University of Texas M.D. Anderson Cancer Center, 1400 Pressler, Unit 1475, Houston, TX, 77030, USA. 4. Department of Biostatistics, The University of Texas M.D. Anderson Cancer Center, 1400 Pressler, Unit 1411, Houston, TX, 77030, USA. 5. Department of Biostatistics, The University of Texas M.D. Anderson Cancer Center, 1400 Pressler, Unit 1411, Houston, TX, 77030, USA. bamini@mdanderson.org.
Abstract
OBJECTIVE: To determine if focal increased uptake at the rotator interval (RI) and/or inferior capsule (IC) on18F-FDG PET/CT ("positive PET") predicts the presence of adhesive capsulitis (AC). MATERIALS AND METHODS: Three populations were retrospectively examined. Group 1 included 1,137 consecutive 18F-FDG PET/CT studies and was used to determine the prevalence of focal uptake at the RI or IC. Group 2 included 361 cases from a 10-year period with 18F-FDG PET/CT and MRI of shoulder performed within 45 days of each other and was used to enrich the study group. Group 3 included 109 randomly selected patients from the same time frame as groups 1 and 2 and was used to generate the control group. The study group consisted of 15 cases from the three groups, which had positive PET findings. PET/CT images were assessed in consensus by two musculoskeletal radiologists. The reference standard for a diagnosis of AC was clinical and was made by review of the medical record by a pain medicine physician. RESULTS: The prevalence of focal activity at either the RI or IC ("positive PET") was 0.53%. Nine patients had a clinical diagnosis of AC and 15 patients had a positive PET. The sensitivity and specificity of PET for detection of AC was 56% and 87%, respectively. PET/CT had a positive likelihood ratio for AC of 6.3 (95% CI: 2.8-14.6). CONCLUSIONS: Increased uptake at the RI or IC on PET/CT confers a moderate increase in the likelihood of AC.
OBJECTIVE: To determine if focal increased uptake at the rotator interval (RI) and/or inferior capsule (IC) on18F-FDG PET/CT ("positive PET") predicts the presence of adhesive capsulitis (AC). MATERIALS AND METHODS: Three populations were retrospectively examined. Group 1 included 1,137 consecutive 18F-FDG PET/CT studies and was used to determine the prevalence of focal uptake at the RI or IC. Group 2 included 361 cases from a 10-year period with 18F-FDG PET/CT and MRI of shoulder performed within 45 days of each other and was used to enrich the study group. Group 3 included 109 randomly selected patients from the same time frame as groups 1 and 2 and was used to generate the control group. The study group consisted of 15 cases from the three groups, which had positive PET findings. PET/CT images were assessed in consensus by two musculoskeletal radiologists. The reference standard for a diagnosis of AC was clinical and was made by review of the medical record by a pain medicine physician. RESULTS: The prevalence of focal activity at either the RI or IC ("positive PET") was 0.53%. Nine patients had a clinical diagnosis of AC and 15 patients had a positive PET. The sensitivity and specificity of PET for detection of AC was 56% and 87%, respectively. PET/CT had a positive likelihood ratio for AC of 6.3 (95% CI: 2.8-14.6). CONCLUSIONS: Increased uptake at the RI or IC on PET/CT confers a moderate increase in the likelihood of AC.
Authors: Ernst H Elzinga; Conny J van der Laken; Emile F I Comans; Ronald Boellaard; Otto S Hoekstra; Ben A C Dijkmans; Adriaan A Lammertsma; Alexandre E Voskuyl Journal: J Nucl Med Date: 2010-12-13 Impact factor: 10.057
Authors: Pedro A Gondim Teixeira; Clémence Balaj; Anne Chanson; Sophie Lecocq; Matthias Louis; Alain Blum Journal: AJR Am J Roentgenol Date: 2012-06 Impact factor: 3.959
Authors: Eric Wandler; Elissa L Kramer; Orrin Sherman; James Babb; Jean Scarola; Mahvash Rafii Journal: AJR Am J Roentgenol Date: 2005-09 Impact factor: 3.959
Authors: Shelby L Kubicki; Michael L Richardson; Thomas Martin; Eric Rohren; Wei Wei; Behrang Amini Journal: Skeletal Radiol Date: 2014-10-07 Impact factor: 2.199
Authors: Gui Tran; Paul Cowling; Toby Smith; Julie Bury; Adam Lucas; Andrew Barr; Sarah R Kingsbury; Philip G Conaghan Journal: Arthritis Care Res (Hoboken) Date: 2018-06-06 Impact factor: 4.794