Breno S Diniz1, Antonio L Teixeira2, Fei Cao3, Ariel Gildengers4, Jair C Soares2, Meryl A Butters4, Charles F Reynolds4. 1. Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX; Harris County Psychiatric Center, The University of Texas Health Science Center at Houston, Houston, TX. Electronic address: breno.satlerdeoliveiradiniz@uth.tmc.edu. 2. Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX; Harris County Psychiatric Center, The University of Texas Health Science Center at Houston, Houston, TX. 3. Harris County Psychiatric Center, The University of Texas Health Science Center at Houston, Houston, TX. 4. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Abstract
OBJECTIVE: We carried out a systematic review and meta-analysis to evaluate whether history of bipolar disorder (BD) increases the risk of dementia. METHODS: We searched PubMed and Scopus to identify studies that evaluated the risk of dementia in individuals with a history of BD. A total of 6 studies including 3,026 individuals with history of BD and 191,029 non-BD individuals were included in the meta-analysis. RESULTS: History of BD significantly increased the risk of diagnosis of dementia (pooled odds ratio: 2.36; 95% confidence interval: 1.36-4.09; z = 3.07, p < 0.001). Evidence of heterogeneity and of publication bias in the analysis was found. CONCLUSION: History of BD is associated with significantly higher risk of dementia in older adults. Future studies are necessary to evaluate the potential mediators of this association and to evaluate interventions that may reduce the risk of dementia in this population.
OBJECTIVE: We carried out a systematic review and meta-analysis to evaluate whether history of bipolar disorder (BD) increases the risk of dementia. METHODS: We searched PubMed and Scopus to identify studies that evaluated the risk of dementia in individuals with a history of BD. A total of 6 studies including 3,026 individuals with history of BD and 191,029 non-BD individuals were included in the meta-analysis. RESULTS: History of BD significantly increased the risk of diagnosis of dementia (pooled odds ratio: 2.36; 95% confidence interval: 1.36-4.09; z = 3.07, p < 0.001). Evidence of heterogeneity and of publication bias in the analysis was found. CONCLUSION: History of BD is associated with significantly higher risk of dementia in older adults. Future studies are necessary to evaluate the potential mediators of this association and to evaluate interventions that may reduce the risk of dementia in this population.
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