Justin T Brady1, Benjamin P Crawshaw2, Barrington Murrell3, Eslam M G Dosokey2, Murad A Jabir2, Scott R Steele2, Sharon L Stein2, Harry L Reynolds4. 1. Department of Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USA. Electronic address: justin.brady@uhhospitals.org. 2. Department of Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USA. 3. Lake Erie College of Osteopathic Medicine, Erie, PA, USA. 4. Department of Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USA. Electronic address: Harry.Reynolds@UHhospitals.org.
Abstract
BACKGROUND: Intraoperative radiation therapy (IORT) has been proposed as a tool to improve local control in patients with locally advanced primary or recurrent colorectal cancer. METHODS: A retrospective review (1999-2015) of all patients undergoing IORT for locally advanced or recurrent colorectal cancer at a single academic center was performed. Patient demographics, oncologic staging, short-term and long-term outcomes were reviewed. RESULTS: There were 77 patients (mean age 63 ± 11 years) identified, of whom 19 had colon cancer, 57 had rectal cancer, and 2 had appendiceal cancers. R0 resection was performed in 53 patients (69%), R1 in 19 (25%) and R2 in 5 (6%). Ten (13%) patients had a local recurrence at 18 ± 14 months and 34 (44%) had a distant recurrence at 18 ± 18 months. Mean survival was 47 ± 41 months. CONCLUSION: IORT resulted in low local failure rates and should be considered for patients with locally advanced or recurrent colorectal cancers.
BACKGROUND: Intraoperative radiation therapy (IORT) has been proposed as a tool to improve local control in patients with locally advanced primary or recurrent colorectal cancer. METHODS: A retrospective review (1999-2015) of all patients undergoing IORT for locally advanced or recurrent colorectal cancer at a single academic center was performed. Patient demographics, oncologic staging, short-term and long-term outcomes were reviewed. RESULTS: There were 77 patients (mean age 63 ± 11 years) identified, of whom 19 had colon cancer, 57 had rectal cancer, and 2 had appendiceal cancers. R0 resection was performed in 53 patients (69%), R1 in 19 (25%) and R2 in 5 (6%). Ten (13%) patients had a local recurrence at 18 ± 14 months and 34 (44%) had a distant recurrence at 18 ± 18 months. Mean survival was 47 ± 41 months. CONCLUSION: IORT resulted in low local failure rates and should be considered for patients with locally advanced or recurrent colorectal cancers.
Authors: Felipe A Calvo; Claudio V Sole; Harm J Rutten; Wim J Dries; Miguel A Lozano; Mauricio Cambeiro; Philip Poortmans; Luis González-Bayón Journal: Clin Transl Radiat Oncol Date: 2020-06-17
Authors: Li Ma; Junhao Qiang; Heliang Yin; Lin Lin; Yan Jiao; Changying Ma; Xinwei Li; Li Dong; Jinglin Cui; Dongmei Wei; Ankur M Sharma; David L Schwartz; Weikuan Gu; Hong Chen Journal: World J Surg Oncol Date: 2020-06-17 Impact factor: 2.754