Lin Lin1,2, Kui Peng1,2, Rui Du1,2, Xiaolin Huang1,2, Jieli Lu1,2, Yu Xu1,2, Min Xu1,2, Yuhong Chen1,2,3, Yufang Bi1,2, Weiqing Wang1,2. 1. State Key Laboratory of Medical Genomics, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2. Shanghai Institute of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3. Department of Endocrine and Metabolic Diseases, Rui Jin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Abstract
OBJECTIVE: To investigate the association between the metabolically healthy obesity (MHO) phenotype and incident chronic kidney disease (CKD) in a Chinese population and whether systemic inflammation affects this association. METHODS: A cohort study was performed with 2,491 Chinese adults. Body mass index ≥ 25.0 kg/m2 was defined as obesity. CKD was defined as estimated glomerular filtration rate < 60 mL/min per 1.73 m2 or urinary albumin-to-creatinine ratio ≥ 30 mg/g. High-sensitivity C-reactive protein (hsCRP) was used as a surrogate marker of systemic inflammation. RESULTS: Over a median follow-up period of 3.9 years, 243 of 2,491 participants developed incident CKD (9.8%). Compared with metabolically healthy nonobesity (MHNO), MHO was associated with incident CKD (odds ratio [OR] = 1.65, 95% confidence interval [CI] 1.01-2.69), but not after adjustment for hsCRP. The MHO/hsCRP ≥ 0.20 mg/L group, but not the MHO/hsCRP < 0.20 mg/L group, had an increased OR for incident CKD (OR = 2.66, 95% CI 1.37-5.14), with the MHNO/hsCRP < 0.20 mg/L group as the reference. CONCLUSIONS: MHO was significantly associated with incident CKD, and the level of systemic inflammation partially explained this association.
OBJECTIVE: To investigate the association between the metabolically healthy obesity (MHO) phenotype and incident chronic kidney disease (CKD) in a Chinese population and whether systemic inflammation affects this association. METHODS: A cohort study was performed with 2,491 Chinese adults. Body mass index ≥ 25.0 kg/m2 was defined as obesity. CKD was defined as estimated glomerular filtration rate < 60 mL/min per 1.73 m2 or urinary albumin-to-creatinine ratio ≥ 30 mg/g. High-sensitivity C-reactive protein (hsCRP) was used as a surrogate marker of systemic inflammation. RESULTS: Over a median follow-up period of 3.9 years, 243 of 2,491 participants developed incident CKD (9.8%). Compared with metabolically healthy nonobesity (MHNO), MHO was associated with incident CKD (odds ratio [OR] = 1.65, 95% confidence interval [CI] 1.01-2.69), but not after adjustment for hsCRP. The MHO/hsCRP ≥ 0.20 mg/L group, but not the MHO/hsCRP < 0.20 mg/L group, had an increased OR for incident CKD (OR = 2.66, 95% CI 1.37-5.14), with the MHNO/hsCRP < 0.20 mg/L group as the reference. CONCLUSIONS: MHO was significantly associated with incident CKD, and the level of systemic inflammation partially explained this association.
Authors: Todd R Sponholtz; Edwin R van den Heuvel; Vanessa Xanthakis; Ramachandran S Vasan Journal: J Am Heart Assoc Date: 2019-04-02 Impact factor: 5.501
Authors: Hai-Hua Chuang; Rong-Ho Lin; Wen-Cheng Li; Wei-Chung Yeh; Yen-An Lin; Jau-Yuan Chen Journal: Int J Environ Res Public Health Date: 2020-08-13 Impact factor: 4.614