Hugo Vilhena1,2,3, Asta Tvarijonaviciute4,5, José J Cerón5, Lisete Vieira6, Josep Pastor4, Ana C Silvestre-Ferreira3,6. 1. Department of Veterinary Medicine, Vasco da Gama Universitary School, Coimbra, Portugal. 2. Baixo Vouga Veterinary Hospital, Águeda, Portugal. 3. Animal and Veterinary Research Centre (CECAV), Trás-os-Montes and Alto Douro University, Vila Real, Portugal. 4. Department of Animal Medicine and Surgery, Autonomous University of Barcelona, Barcelona, Spain. 5. Interdisciplinary Laboratory of Clinical Analysis Interlab-UMU, University of Murcia, Murcia, Spain. 6. Department of Veterinary Sciences, Trás-os-Montes and Alto Douro University, Vila Real, Portugal.
Abstract
BACKGROUND: The measurement of acute phase proteins (APP) is being increasingly used in human and veterinary medicine in diagnosis, prognosis, treatment monitoring, and in general health screening. However, information about the APP response in cats infected with agents of vector-borne diseases is lacking. OBJECTIVES: The purpose of the study was to investigate the concentrations of serum amyloid A (SAA), haptoglobin (Hp), and paraoxonase-1 (PON1) in cats naturally infected with Hepatozoon felis and Babesia vogeli. METHODS: Serum concentrations of SAA, Hp, and PON1 were determined in 19 cats naturally infected with H felis and in 11 cats naturally infected with B vogeli, and compared to concentrations in 10 healthy control cats. RESULTS: Serum Hp concentrations were significantly increased, and PON1 concentrations significantly decreased in symptomatic and asymptomatic cats infected with H felis and B vogeli when compared with healthy noninfected cats. In the H felis-infected population, concentrations of SAA and Hp were significantly increased in symptomatic cats when compared with asymptomatic animals. CONCLUSIONS: This study demonstrated differences in APP concentrations in cats infected with H felis and B vogeli. Therefore, Hp and PON1 concentrations could be helpful in discriminating healthy cats from cats with asymptomatic or symptomatic infection by these agents.
BACKGROUND: The measurement of acute phase proteins (APP) is being increasingly used in human and veterinary medicine in diagnosis, prognosis, treatment monitoring, and in general health screening. However, information about the APP response in cats infected with agents of vector-borne diseases is lacking. OBJECTIVES: The purpose of the study was to investigate the concentrations of serum amyloid A (SAA), haptoglobin (Hp), and paraoxonase-1 (PON1) in cats naturally infected with Hepatozoon felis and Babesia vogeli. METHODS: Serum concentrations of SAA, Hp, and PON1 were determined in 19 cats naturally infected with H felis and in 11 cats naturally infected with B vogeli, and compared to concentrations in 10 healthy control cats. RESULTS: Serum Hp concentrations were significantly increased, and PON1 concentrations significantly decreased in symptomatic and asymptomatic cats infected with H felis and B vogeli when compared with healthy noninfected cats. In the H felis-infected population, concentrations of SAA and Hp were significantly increased in symptomatic cats when compared with asymptomatic animals. CONCLUSIONS: This study demonstrated differences in APP concentrations in cats infected with H felis and B vogeli. Therefore, Hp and PON1 concentrations could be helpful in discriminating healthy cats from cats with asymptomatic or symptomatic infection by these agents.
Authors: Susana Remesar; Jose Luis Arnal; Andrea Gómez; Alberto Prieto; David García-Dios; Alfredo Benito; Rosario Panadero; Patrocinio Morrondo; Pablo Díaz Journal: BMC Vet Res Date: 2022-05-14 Impact factor: 2.792
Authors: Marion L East; Bettina Wachter; Jürgen Krücken; Gábor Á Czirják; Sabrina Ramünke; Maria Serocki; Sonja K Heinrich; Jörg Melzheimer; M Carolina Costa; Heribert Hofer; Ortwin H K Aschenborn; Nancy A Barker; Stefano Capodanno; Luís Madeira de Carvalho; Georg von Samson-Himmelstjerna Journal: Parasit Vectors Date: 2021-06-16 Impact factor: 3.876