| Literature DB >> 28160177 |
Chunhong Liu1,2,3, Yuting Lai4, Junyan Ouyang4, Tongwang Yang4, Youting Guo4, Jie Yang4, Shaowen Huang4.
Abstract
Nonylphenol (NP) and octylphenol (OP) are priority environmental contaminants that have a potential role as endocrine disruptors. They can be biomagnified in the food chain and pose an estrogenic health risk to human health. A 28-day oral toxicity study was performed to observe the impact of single and combined exposure to NP and OP on 5-HT transporter (SERT) as well as 5-HT2A receptor. Results showed that the 5-HT levels in rat plasma increased with exposure to middle-dose and high-dose NP, to high-dose OP, and to low, middle, and high doses of combined NP and OP (P < 0.05), while the 5-HT levels in rat platelets increased when exposed to NP/OP or combined NP and OP of middle or high dose (P < 0.05). The expression levels of SERT in rat platelets decreased when exposed to high-dose NP/OP or high dose of combined NP and OP (P < 0.05). Meanwhile, the expression levels of 5-HT2A in rat platelets decreased when exposed to high-dose NP/OP as well as combined NP and OP (P < 0.05). These findings suggested that exposure to NP and OP could influence the metabolic network of 5-hydroxytryptamine via transportation and receptor binding pathways.Entities:
Keywords: 5-HT2A receptor; 5-Hydroxytryptamine; 5-Hydroxytryptamine transporter; Exposure; Nonylphenol; Octylphenol
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Year: 2017 PMID： 28160177 DOI： 10.1007/s11356-017-8487-6
Source DB: PubMed Journal: Environ Sci Pollut Res Int ISSN： 0944-1344 Impact factor: 4.223