Literature DB >> 28160046

Eag1 Voltage-Dependent Potassium Channels: Structure, Electrophysiological Characteristics, and Function in Cancer.

Xuzhao Wang1,2, Yafei Chen2, Yuhong Zhang2, Shuai Guo1,2, Li Mo2, Hailong An3, Yong Zhan4,5.   

Abstract

Eag1 (ether-à-go-go-1), a member of the voltage-dependent potassium channel family, is expressed mainly in the brain, and at low levels in placenta, testis, and adrenal gland, and only transiently in myoblasts. Recently, several studies have suggested that Eag1 is selectively expressed in various tumor tissues. Eag1 plays important roles in tumor proliferation, malignant transformation, invasion, metastasis, recurrence, and prognosis. Therefore, it has become a new molecular target for tumor diagnosis, prognosis evaluation, and tumor-targeted therapy. This review provides information about the current progress in understanding Eag1 structure, electrophysiological characteristics, and role in cancer.

Entities:  

Keywords:  Cancer; Eag1; Electrophysiology; Molecular structure; p53

Mesh：

Substances：

Year:  2017        PMID： 28160046     DOI： 10.1007/s00232-016-9944-8

Source DB:  PubMed          Journal:  J Membr Biol        ISSN： 0022-2631            Impact factor:   1.843


  86 in total

1.  Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide.

Authors:  David Gómez-Varela; Constanza Contreras-Jurado; Simone Furini; Rafael García-Ferreiro; Walter Stühmer; Luis A Pardo
Journal:  FEBS Lett       Date:  2006-08-28       Impact factor: 4.124

2.  Human papillomavirus type 16 E7 binds to E2F1 and activates E2F1-driven transcription in a retinoblastoma protein-independent manner.

Authors:  Sun Gwan Hwang; Daeyoup Lee; Jiyun Kim; Taegun Seo; Joonho Choe
Journal:  J Biol Chem       Date:  2001-11-16       Impact factor: 5.157

3.  Astemizole-based anticancer therapy for hepatocellular carcinoma (HCC), and Eag1 channels as potential early-stage markers of HCC.

Authors:  María de Guadalupe Chávez-López; Julio Isael Pérez-Carreón; Violeta Zuñiga-García; José Díaz-Chávez; Luis A Herrera; Claudia Haydee Caro-Sánchez; Isabel Acuña-Macías; Patricio Gariglio; Elizabeth Hernández-Gallegos; Andrea Jazmín Chiliquinga; Javier Camacho
Journal:  Tumour Biol       Date:  2015-03-18

Review 4.  The roles of K(+) channels in cancer.

Authors:  Luis A Pardo; Walter Stühmer
Journal:  Nat Rev Cancer       Date:  2013-12-12       Impact factor: 60.716

5.  Cytoskeletal interactions determine the electrophysiological properties of human EAG potassium channels.

Authors:  J Camacho; A Sánchez; W Stühmer; L A Pardo
Journal:  Pflugers Arch       Date:  2000-12       Impact factor: 3.657

6.  Oncogenic potential of EAG K(+) channels.

Authors:  L A Pardo; D del Camino; A Sánchez; F Alves; A Brüggemann; S Beckh; W Stühmer
Journal:  EMBO J       Date:  1999-10-15       Impact factor: 11.598

Review 7.  hERG potassium channels and cardiac arrhythmia.

Authors:  Michael C Sanguinetti; Martin Tristani-Firouzi
Journal:  Nature       Date:  2006-03-23       Impact factor: 49.962

8.  Mechanism of block of hEag1 K+ channels by imipramine and astemizole.

Authors:  Rafael E García-Ferreiro; Daniel Kerschensteiner; Felix Major; Francisco Monje; Walter Stühmer; Luis A Pardo
Journal:  J Gen Physiol       Date:  2004-09-13       Impact factor: 4.086

9.  hERG potassium channel gating is mediated by N- and C-terminal region interactions.

Authors:  Ahleah S Gustina; Matthew C Trudeau
Journal:  J Gen Physiol       Date:  2011-03       Impact factor: 4.086

10.  MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region.

Authors:  A-rum Yoon; Ran Gao; Zeenia Kaul; Il-Kyu Choi; Jihoon Ryu; Jane R Noble; Yoshio Kato; Soichiro Saito; Takashi Hirano; Tetsuro Ishii; Roger R Reddel; Chae-Ok Yun; Sunil C Kaul; Renu Wadhwa
Journal:  Nucleic Acids Res       Date:  2011-06-30       Impact factor: 16.971
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  4 in total

1.  Methadone-mediated sensitization of glioblastoma cells is drug and cell line dependent.

Authors:  Bodo Haas; Janine Ciftcioglu; Sanja Jermar; Sandra Weickhardt; Niels Eckstein; Bernd Kaina
Journal:  J Cancer Res Clin Oncol       Date:  2020-12-14       Impact factor: 4.553

2.  Potassium Channel KCNH1 Activating Variants Cause Altered Functional and Morphological Ciliogenesis.

Authors:  Giulia Napoli; Noemi Panzironi; Alice Traversa; Caterina Catalanotto; Valentina Pace; Francesco Petrizzelli; Agnese Giovannetti; Sara Lazzari; Carlo Cogoni; Marco Tartaglia; Massimo Carella; Tommaso Mazza; Antonio Pizzuti; Chiara Parisi; Viviana Caputo
Journal:  Mol Neurobiol       Date:  2022-05-31       Impact factor: 5.682

Review 3.  Potassium Channels as a Target for Cancer Therapy: Current Perspectives.

Authors:  Leandro Zúñiga; Angel Cayo; Wendy González; Cristian Vilos; Rafael Zúñiga
Journal:  Onco Targets Ther       Date:  2022-07-20       Impact factor: 4.345

4.  Eag1 Gene and Protein Expression in Human Retinoblastoma Tumors and its Regulation by pRb in HeLa Cells.

Authors:  María de Guadalupe Chávez-López; Violeta Zúñiga-García; Blanca Elena Castro-Magdonel; Eunice Vera; Efraín Garrido; Janet Sánchez-Ramos; M Verónica Ponce-Castañeda; M de Lourdes Cabrera-Muñoz; Yesenia Escobar; Cindy Sharon Ortiz; Elisabeth Hernández-Gallegos; Arturo Avalos-Fuentes; Javier Camacho
Journal:  Genes (Basel)       Date:  2020-01-21       Impact factor: 4.096
  4 in total

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