| Literature DB >> 28159829 |
Jennifer C Rodrigues1, Mark Haas2, Heather N Reich3,4.
Abstract
IgA nephropathy (IgAN) is a leading cause of CKD and renal failure. Recent international collaborative efforts have led to important discoveries that have improved our understanding of some of the key steps involved in the immunopathogenesis of IgAN. Furthermore, establishment of multicenter networks has contributed to rigorous design and execution of clinical trials that have provided important insights regarding immunotherapy in IgAN. In this article, we review emerging developments in clinical and translational IgAN research and describe how these novel findings will influence future strategies to improve the outcome of patients with IgAN.Entities:
Keywords: IGA; IgA nephropathy; chronic; corticosteroids; crescents; glomerulonephritis; humans; immunosuppression; immunotherapy; kidney; pathology; renal insufficiency; review; translational medical research
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Year: 2017 PMID: 28159829 PMCID: PMC5383386 DOI: 10.2215/CJN.07420716
Source DB: PubMed Journal: Clin J Am Soc Nephrol ISSN: 1555-9041 Impact factor: 8.237