Nikolaj Jangaard1, Laura Sarkisian1, Lotte Saaby1, Søren Mikkelsen2, Anne Marie Lassen3, Niels Marcussen4, Jørgen L Thomsen5, Axel C P Diederichsen1, Kristian Thygesen6, Hans Mickley7. 1. Department of Cardiology, Odense University Hospital, Denmark. 2. Mobile Emergency Care Unit, Department of Anesthesiology and Intensive Care, Odense University Hospital, Denmark. 3. Department of Emergency Medicine, Odense University Hospital, Denmark. 4. Institute of Pathology, Odense University Hospital, Denmark. 5. Institute of Forensic Medicine, Odense University Hospital, Denmark. 6. Department of Cardiology, Aarhus University Hospital, Denmark. 7. Department of Cardiology, Odense University Hospital, Denmark. Electronic address: Hans.mickley@rsyd.dk.
Abstract
OBJECTIVES: Cardiac death in a patient with symptoms and electrocardiographic changes indicative of myocardial ischemia but without available measurements of cardiac biomarkers is designated a type 3 myocardial infarction. We wanted to investigate the incidence, the frequency, and the characteristics of patients diagnosed as type 3 myocardial infarction. METHODS: The occurrence of deaths in a well-defined geographic region was retrieved from the Danish Civil Registration System during a 1-year period from 2010 to 2011. Complementary data concerning causes of deaths were obtained from the Danish Register of Causes of Death, and ambulance and hospital patient files. Adjudication of the diagnosis was done by 2 local experts and one external senior cardiologist. RESULTS: A total of 2766 of the 246,723 adult residents in the region had died. A type 3 myocardial infarction was diagnosed in 18 individuals, corresponding to an annual incidence of 7.3/100,000 person-years. During the same 1-year period, 488 patients had other types of myocardial infarction implying a 3.6% frequency of type 3 myocardial infarction (18 of 506) among all myocardial infarctions. CONCLUSION: Type 3 myocardial infarction is a rare observation in clinical practice with an annual incidence below 10/100,000 person-years and a frequency of 3%-4% among all types of myocardial infarction. If autopsy data are included, the number of type 3 myocardial infarctions will increase.
OBJECTIVES:Cardiac death in a patient with symptoms and electrocardiographic changes indicative of myocardial ischemia but without available measurements of cardiac biomarkers is designated a type 3 myocardial infarction. We wanted to investigate the incidence, the frequency, and the characteristics of patients diagnosed as type 3 myocardial infarction. METHODS: The occurrence of deaths in a well-defined geographic region was retrieved from the Danish Civil Registration System during a 1-year period from 2010 to 2011. Complementary data concerning causes of deaths were obtained from the Danish Register of Causes of Death, and ambulance and hospital patient files. Adjudication of the diagnosis was done by 2 local experts and one external senior cardiologist. RESULTS: A total of 2766 of the 246,723 adult residents in the region had died. A type 3 myocardial infarction was diagnosed in 18 individuals, corresponding to an annual incidence of 7.3/100,000 person-years. During the same 1-year period, 488 patients had other types of myocardial infarction implying a 3.6% frequency of type 3 myocardial infarction (18 of 506) among all myocardial infarctions. CONCLUSION: Type 3 myocardial infarction is a rare observation in clinical practice with an annual incidence below 10/100,000 person-years and a frequency of 3%-4% among all types of myocardial infarction. If autopsy data are included, the number of type 3 myocardial infarctions will increase.
Authors: Katarzyna Michaud; Cristina Basso; Giulia d'Amati; Carla Giordano; Ivana Kholová; Stephen D Preston; Stefania Rizzo; Sara Sabatasso; Mary N Sheppard; Aryan Vink; Allard C van der Wal Journal: Virchows Arch Date: 2019-09-14 Impact factor: 4.064