OBJECTIVES: The main aims of this paper are to review and evaluate the neurobiology of the depressive syndrome from a neurodevelopmental perspective. METHODS: An English language literature search was performed using PubMed. RESULTS: Depression is a complex syndrome that involves anatomical and functional changes that have an early origin in brain development. In subjects with genetic risk for depression, early stress factors are able to mediate not only the genetic risk but also gene expression. There is evidence that endocrine and immune interactions have an important impact on monoamine function and that the altered monoamine signalling observed in the depressive syndrome has a neuro-endocrino-immunological origin early in the development. CONCLUSIONS: Neurodevelopment is a key aspect to understand the whole neurobiology of depression.
OBJECTIVES: The main aims of this paper are to review and evaluate the neurobiology of the depressive syndrome from a neurodevelopmental perspective. METHODS: An English language literature search was performed using PubMed. RESULTS:Depression is a complex syndrome that involves anatomical and functional changes that have an early origin in brain development. In subjects with genetic risk for depression, early stress factors are able to mediate not only the genetic risk but also gene expression. There is evidence that endocrine and immune interactions have an important impact on monoamine function and that the altered monoamine signalling observed in the depressive syndrome has a neuro-endocrino-immunological origin early in the development. CONCLUSIONS: Neurodevelopment is a key aspect to understand the whole neurobiology of depression.
Authors: Amanda G Bertollo; Roberta E Grolli; Marcos E Plissari; Vanessa A Gasparin; João Quevedo; Gislaine Z Réus; Margarete D Bagatini; Zuleide M Ignácio Journal: AIMS Neurosci Date: 2020-11-13
Authors: Tsutomu Takahashi; Daiki Sasabayashi; Murat Yücel; Sarah Whittle; Valentina Lorenzetti; Mark Walterfang; Michio Suzuki; Christos Pantelis; Gin S Malhi; Nicholas B Allen Journal: Front Hum Neurosci Date: 2022-06-13 Impact factor: 3.473
Authors: Lucas Fornari Laurindo; Sandra Maria Barbalho; Elen Landgraf Guiguer; Maricelma da Silva Soares de Souza; Gabriela Achete de Souza; Thiago Marques Fidalgo; Adriano Cressoni Araújo; Heron F de Souza Gonzaga; Daniel de Bortoli Teixeira; Thais de Oliveira Silva Ullmann; Katia Portero Sloan; Lance Alan Sloan Journal: Int J Mol Sci Date: 2022-01-10 Impact factor: 5.923