Guillaume Costalat1,2, Frederic Lemaitre3, Barbara Tobin4, Gillian Renshaw4. 1. Faculty of Sport Sciences, CETAPS Laboratory, EA 3832, Normandy University, Rouen, France. Guillaume.costalat@gmail.com. 2. Faculty of Sport Sciences, APERE Laboratory, EA 3300, University of Picardie Jules Verne, Amiens, France. Guillaume.costalat@gmail.com. 3. Faculty of Sport Sciences, CETAPS Laboratory, EA 3832, Normandy University, Rouen, France. 4. Hypoxia and Ischemia Research Unit, School of Rehabilitation Sciences, Griffith University Gold Coast Campus, Southport, Queensland, Australia.
Abstract
PURPOSE: The study aims to investigate the effects of moderate intermittent hypoxia (IH) on key cardio-metabolic risk factors in overweight and obese subjects. METHODS: Six subjects were exposed to 10 sessions of moderate IH over 2 weeks (based on [Formula: see text]; ~70 min per session). Measures were made of blood glucose (GLU) and lactate (La-); high (HDLc) and low-density lipoproteins (LDLc); triglycerides (TRG), systolic (SBP), and diastolic blood pressure (DBP); and cardiac autonomic indices [root mean square of successive R-R interval differences (RMSSD) and short-term fractal scaling exponent (DFAα1)]. RESULTS: GLU decreased and La- increased following a single IH session (6.21 ± 1.62 vs. 5.32 ± 1.03 mmol L-1; p < 0.05; 1.14 ± 0.21 vs. 1.47 ± 0.22 mmol L-1), but no sustained change after 10 sessions of IH occurred (p > 0.05). Conversely, LDLc (3.00 ± 0.68 vs. 2.51 ± 0.60 mmol L-1; p < 0.05), LDLc/HDLc ratio (2.52 ± 0.66 vs. 2.26 ± 0.70 mmol L-1; p < 0.05), and SBP (118.6 ± 13.3 vs. 109.6 ± 11.3 mmHg; p < 0.05) were all significantly decreased after 10 sessions. CONCLUSION: A short course of recurrent IH appears to be a safe and effective non-pharmacological method of reducing key cardiovascular risk factors associated with metabolic disorders.
PURPOSE: The study aims to investigate the effects of moderate intermittent hypoxia (IH) on key cardio-metabolic risk factors in overweight and obese subjects. METHODS: Six subjects were exposed to 10 sessions of moderate IH over 2 weeks (based on [Formula: see text]; ~70 min per session). Measures were made of blood glucose (GLU) and lactate (La-); high (HDLc) and low-density lipoproteins (LDLc); triglycerides (TRG), systolic (SBP), and diastolic blood pressure (DBP); and cardiac autonomic indices [root mean square of successive R-R interval differences (RMSSD) and short-term fractal scaling exponent (DFAα1)]. RESULTS:GLU decreased and La- increased following a single IH session (6.21 ± 1.62 vs. 5.32 ± 1.03 mmol L-1; p < 0.05; 1.14 ± 0.21 vs. 1.47 ± 0.22 mmol L-1), but no sustained change after 10 sessions of IH occurred (p > 0.05). Conversely, LDLc (3.00 ± 0.68 vs. 2.51 ± 0.60 mmol L-1; p < 0.05), LDLc/HDLc ratio (2.52 ± 0.66 vs. 2.26 ± 0.70 mmol L-1; p < 0.05), and SBP (118.6 ± 13.3 vs. 109.6 ± 11.3 mmHg; p < 0.05) were all significantly decreased after 10 sessions. CONCLUSION: A short course of recurrent IH appears to be a safe and effective non-pharmacological method of reducing key cardiovascular risk factors associated with metabolic disorders.
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