Literature DB >> 28154750

Potentiation of the Fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida.

Matthew D Stephens1, Nisakorn Yodsanit2, Christian Melander1.   

Abstract

A library of 33 compounds was screened for potentiation of the antibiotic FR 900098 against the Francisella tularensis surrogate Francisella novicida. From the screen a highly potent 2-oxazoline adjuvant was discovered capable of potentiating FR 900098 with a 1000-fold reduction in MIC against the Francisella sub-species F. novicida and F. philomiragia.

Entities:  

Year:  2016        PMID： 28154750      PMCID： PMC5279706          DOI： 10.1039/C6MD00365F

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  20 in total

1.  Recent developments in the application of oxazoline-containing ligands in asymmetric catalysis.

Authors:  Helen A McManus; Patrick J Guiry
Journal:  Chem Rev       Date:  2004-09       Impact factor: 60.622

Review 2.  Recent applications of oxazoline-containing ligands in asymmetric catalysis.

Authors:  Gráinne C Hargaden; Patrick J Guiry
Journal:  Chem Rev       Date:  2009-06       Impact factor: 60.622

3.  Antibacterial agents that inhibit lipid A biosynthesis.

Authors:  H R Onishi; B A Pelak; L S Gerckens; L L Silver; F M Kahan; M H Chen; A A Patchett; S M Galloway; S A Hyland; M S Anderson; C R Raetz
Journal:  Science       Date:  1996-11-08       Impact factor: 47.728

4.  Modulation of biogenesis of the Francisella tularensis subsp. novicida-containing phagosome in quiescent human macrophages and its maturation into a phagolysosome upon activation by IFN-gamma.

Authors:  Marina Santic; Maelle Molmeret; Yousef Abu Kwaik
Journal:  Cell Microbiol       Date:  2005-07       Impact factor: 3.715

Review 5.  Isoprenoid metabolism as a therapeutic target in gram-negative pathogens.

Authors:  Andrew J Wiemer; Chia-Hung Christine Hsiao; David F Wiemer
Journal:  Curr Top Med Chem       Date:  2010       Impact factor: 3.295

6.  Highly regioselective palladium-catalyzed direct arylation of oxazole at C-2 or C-5 with aryl bromides, chlorides, and triflates.

Authors:  Neil A Strotman; Harry R Chobanian; Yan Guo; Jiafang He; Jonathan E Wilson
Journal:  Org Lett       Date:  2010-08-20       Impact factor: 6.005

Review 7.  Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme.

Authors:  Nidhi Singh; Gweneal Chevé; Mitchell A Avery; Christopher R McCurdy
Journal:  Curr Pharm Des       Date:  2007       Impact factor: 3.116

8.  A new family of enzymes catalyzing the first committed step of the methylerythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis in bacteria.

Authors:  Félix J Sangari; Jordi Pérez-Gil; Lorenzo Carretero-Paulet; Juan M García-Lobo; Manuel Rodríguez-Concepción
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-26       Impact factor: 11.205

9.  Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase).

Authors:  Safdar Jawaid; Heather Seidle; Weidong Zhou; Hafsa Abdirahman; Maher Abadeer; Joseph H Hix; Monique L van Hoek; Robin D Couch
Journal:  PLoS One       Date:  2009-12-14       Impact factor: 3.240

10.  Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake.

Authors:  Amanda C Brown; Tanya Parish
Journal:  BMC Microbiol       Date:  2008-05-20       Impact factor: 3.605
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  1 in total

1.  Esterification of Aryl/Alkyl Acids Catalysed by N-bromosuccinimide under Mild Reaction Conditions.

Authors:  Klara Čebular; Bojan Đ Božić; Stojan Stavber
Journal:  Molecules       Date:  2018-09-02       Impact factor: 4.411
  1 in total

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