Literature DB >> 281540

Genealogy of cancer in a family.

W A Blattner, D B McGuire, J J Mulvihill, B C Lampkin, J Hananian, J F Fraumeni.   

Abstract

Three brothers had separate childhood cancers--osteogenic sarcoma, acute lymphoblastic leukemia, and bilateral malignant neurilemoma. Comprehensive family history showed a total of 16 cases of cancer among the descendants of the proband's great-great-great-grandmother, including a previously unsuspected cluster of similar neoplasms in an distant branch. The constellation of tumors in the family included bony and soft-tissue sarcomas, brain and neural tumors, leukemia, and breast carcinoma, occurring in a pattern suggesting the action of an incompletely penetrant autosomal dominant gene with pleiotropic effects. In some cases the genetic predisposition may have interacted with environmental determinants to produce particular tumors.

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Mesh：

Year:  1979        PMID： 281540

Source DB:  PubMed          Journal:  JAMA        ISSN： 0098-7484            Impact factor:   56.272


  9 in total

1.  Two families with the Li-Fraumeni cancer family syndrome.

Authors:  A D Pearson; A W Craft; J M Ratcliffe; J M Birch; P Morris-Jones; D F Roberts
Journal:  J Med Genet       Date:  1982-10       Impact factor: 6.318

2.  Synchronous occurrence of glioblastoma multiforme in a husband and wife.

Authors:  T W Griffin; T W Smith; B S Levy; L D Recht
Journal:  J Neurooncol       Date:  1986       Impact factor: 4.130

3.  Familial glioma: occurrence within the "familial cancer syndrome" and systemic malformations.

Authors:  P Vieregge; L Gerhard; H C Nahser
Journal:  J Neurol       Date:  1987-05       Impact factor: 4.849

4.  p53 mutations increase resistance to ionizing radiation.

Authors:  J M Lee; A Bernstein
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-15       Impact factor: 11.205

5.  Caspase Activation and Aberrant Cell Growth in a p53(+/+) Cell Line from a Li-Fraumeni Syndrome Family.

Authors:  Zaki A Sherif
Journal:  Genet Res Int       Date:  2015-03-18

6.  Aberrant DNA topoisomerase II activity, radioresistance and inherited susceptibility to cancer.

Authors:  J M Cunningham; G E Francis; M J Holland; K F Pirollo; E H Chang
Journal:  Br J Cancer       Date:  1991-01       Impact factor: 7.640

7.  Excess risk of breast cancer in the mothers of children with soft tissue sarcomas.

Authors:  J M Birch; A L Hartley; H B Marsden; M Harris; R Swindell
Journal:  Br J Cancer       Date:  1984-03       Impact factor: 7.640

8.  Breast cancer risk in mothers of children with osteosarcoma and chondrosarcoma.

Authors:  A L Hartley; J M Birch; H B Marsden; M Harris
Journal:  Br J Cancer       Date:  1986-11       Impact factor: 7.640

9.  Abnormal pattern of post-gamma-ray DNA replication in radioresistant fibroblast strains from affected members of a cancer-prone family with Li-Fraumeni syndrome.

Authors:  R Mirzayans; R A Aubin; W Bosnich; W A Blattner; M C Paterson
Journal:  Br J Cancer       Date:  1995-06       Impact factor: 7.640
  9 in total

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