| Literature DB >> 28153670 |
Stella Totti1, Spyros I Vernardis2, Lisiane Meira3, Pedro A Pérez-Mancera4, Eithne Costello5, William Greenhalf6, Daniel Palmer4, John Neoptolemos5, Athanasios Mantalaris2, Eirini G Velliou7.
Abstract
Pancreatic cancer is one of the most aggressive and lethal human malignancies. Drug therapies and radiotherapy are used for treatment as adjuvants to surgery, but outcomes remain disappointing. Advances in tissue engineering suggest that 3D cultures can reflect the in vivo tumor microenvironment and can guarantee a physiological distribution of oxygen, nutrients, and drugs, making them promising low-cost tools for therapy development. Here, we review crucial structural and environmental elements that should be considered for an accurate design of an ex vivo platform for studies of pancreatic cancer. Furthermore, we propose environmental stress response biomarkers as platform readouts for the efficient control and further prediction of the pancreatic cancer response to the environmental and treatment input.Entities:
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Year: 2017 PMID： 28153670 DOI： 10.1016/j.drudis.2017.01.012
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851