Christian Fisahn1, Cameron Schmidt2, Steven Rostad3, Rong Li4, Tarush Rustagi5, Fernando Alonso5, Mohammadali M Shoja6, Joe Iwanaga2, Jens R Chapman5, Rod J Oskouian5, R Shane Tubbs2. 1. Swedish Neuroscience Institute, Swedish Medical Center, Seattle, Washington, USA; Seattle Science Foundation, Seattle, Washington, USA; Department of Trauma Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Germany. Electronic address: christian.fisahn@swedish.org. 2. Seattle Science Foundation, Seattle, Washington, USA. 3. CellNetix Pathology, Seattle, Washington, USA. 4. Department of Pathology, Children's of Alabama, Birmingham, Alabama, USA. 5. Swedish Neuroscience Institute, Swedish Medical Center, Seattle, Washington, USA. 6. Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract
INTRODUCTION: The apical ligament has long been reported to contain notochord remnants and thus might serve as a site of origin of chordoma formation at the skull base. However, to our knowledge, the histologic study of the apical ligament using histologic staining specific for notochordal tissue has not been previously performed. Therefore the current study was undertaken. METHODS: Fifteen apical ligament samples underwent histologic examination with specific markers for notochordal differentiation. RESULTS: Across all samples, there was no indication of any notochordal remnants. CONCLUSIONS: On the basis of our cadaveric study, the apical ligament does not contain notochord tissue and in adults should not be considered a remnant of this structure. Moreover, it is unlikely that the apical ligament gives rise to chordomas at the craniocervical junction under normal circumstances.
INTRODUCTION: The apical ligament has long been reported to contain notochord remnants and thus might serve as a site of origin of chordoma formation at the skull base. However, to our knowledge, the histologic study of the apical ligament using histologic staining specific for notochordal tissue has not been previously performed. Therefore the current study was undertaken. METHODS: Fifteen apical ligament samples underwent histologic examination with specific markers for notochordal differentiation. RESULTS: Across all samples, there was no indication of any notochordal remnants. CONCLUSIONS: On the basis of our cadaveric study, the apical ligament does not contain notochord tissue and in adults should not be considered a remnant of this structure. Moreover, it is unlikely that the apical ligament gives rise to chordomas at the craniocervical junction under normal circumstances.
Authors: Rabjot Rai; Joe Iwanaga; Ghaffar Shokouhi; Marios Loukas; Martin M Mortazavi; Rod J Oskouian; R Shane Tubbs Journal: Childs Nerv Syst Date: 2018-06-28 Impact factor: 1.475
Authors: Tushar Ramesh; Sai V Nagula; Gabrielle G Tardieu; Erfanul Saker; Mohammadali Shoja; Marios Loukas; Rod J Oskouian; R Shane Tubbs Journal: Cureus Date: 2017-04-04