| Literature DB >> 28153357 |
Lara Pes1, Young Kim2, Ching-Hsuan Tung3.
Abstract
A new dendrimer probe was designed for bone imaging. Bidentate iminodiacetate groups were introduced to the probe to obtain strong bind to bones. The assembled dendrimeric probe, with four iminodiacetate moieties and a fluorescent tag, displayed good selectivity to hydroxyapatite, calcium oxalate and calcium phosphate salts. In mice, the probe offered vivid skeletal details after intravenous delivery.Entities:
Keywords: Bone; Dendrimer; Fluorescence imaging; Hydroxyapatite; Iminodiacetate
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Year: 2017 PMID： 28153357 PMCID： PMC5328641 DOI： 10.1016/j.bmcl.2017.01.059
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823