Yu Ji1,2, Robert Flower1, Catherine Hyland1, Nargess Saiepour3, Helen Faddy1,2. 1. Research and Development, Australian Red Cross Blood Service, Brisbane, QLD, Australia. 2. School of Medicine, The University of Queensland, Brisbane, QLD, Australia. 3. School of Population Health, The University of Queensland, Brisbane, QLD, Australia.
Abstract
BACKGROUND: Blood donors are at risk of developing iron deficiency and/or iron deficiency anaemia. This may affect their health and affect their eligibility to give subsequent donations. Investigating genetic factors that may predispose donors to high or low iron stores is of interest; this may assist with providing optimal management strategies for maintaining donor health. This study aimed to investigate whether the presence of selected single nucleotide polymorphisms (SNPs) affecting parameters of iron status were associated with ferritin levels in Australian donors. MATERIALS AND METHODS: Samples (n=800) were collected from non-first-time blood donors in Queensland. Plasma ferritin levels were quantified and the genotypes for ten SNPs, identified by a review of relevant literature, were determined for each sample. Associations between SNPs and ferritin levels were investigated. RESULTS: Three SNPs were associated with ferritin levels. In male donors, high ferritin levels were associated with the variant allele (G) of the SNP rs3923809 in the BTBD9 gene. An association with ferritin levels was also identified with the SNP rs235756 in the BMP2 gene in males. The SNP rs4820268 in the TMPRSS6 gene was associated with ferritin levels in females, with donors with the AG genotype being three times more likely to have low ferritin levels. DISCUSSION: Variants in the genes TMPRSS, BTBD9 and BMP2 were associated with ferritin levels in Australian blood donors. These findings provide support that genetic testing may be useful for the generation of predictive algorithms that may allow for management strategies to be tailor-made for individual donors.
BACKGROUND: Blood donors are at risk of developing iron deficiency and/or iron deficiency anaemia. This may affect their health and affect their eligibility to give subsequent donations. Investigating genetic factors that may predispose donors to high or low iron stores is of interest; this may assist with providing optimal management strategies for maintaining donor health. This study aimed to investigate whether the presence of selected single nucleotide polymorphisms (SNPs) affecting parameters of iron status were associated with ferritin levels in Australian donors. MATERIALS AND METHODS: Samples (n=800) were collected from non-first-time blood donors in Queensland. Plasma ferritin levels were quantified and the genotypes for ten SNPs, identified by a review of relevant literature, were determined for each sample. Associations between SNPs and ferritin levels were investigated. RESULTS: Three SNPs were associated with ferritin levels. In male donors, high ferritin levels were associated with the variant allele (G) of the SNP rs3923809 in the BTBD9 gene. An association with ferritin levels was also identified with the SNP rs235756 in the BMP2 gene in males. The SNP rs4820268 in the TMPRSS6 gene was associated with ferritin levels in females, with donors with the AG genotype being three times more likely to have low ferritin levels. DISCUSSION: Variants in the genes TMPRSS, BTBD9 and BMP2 were associated with ferritin levels in Australian blood donors. These findings provide support that genetic testing may be useful for the generation of predictive algorithms that may allow for management strategies to be tailor-made for individual donors.
Authors: Robert A Moyer; Danxin Wang; Audrey C Papp; Ryan M Smith; Linda Duque; Deborah C Mash; Wolfgang Sadee Journal: Neuropsychopharmacology Date: 2010-12-08 Impact factor: 7.853
Authors: Alan E Mast; Karen S Schlumpf; David J Wright; Brian Custer; Bryan Spencer; Edward L Murphy; Toby L Simon Journal: Transfusion Date: 2010-04-15 Impact factor: 3.157
Authors: Clare C Constantine; Greg J Anderson; Chris D Vulpe; Christine E McLaren; Melanie Bahlo; Heng Lin Yeap; Dorota M Gertig; Nicholas J Osborne; Nadine A Bertalli; Kenneth B Beckman; Victoria Chen; Pavel Matak; Andrew T McKie; Martin B Delatycki; John K Olynyk; Dallas R English; Melissa C Southey; Graham G Giles; John L Hopper; Katrina J Allen; Lyle C Gurrin Journal: Br J Haematol Date: 2009-08-10 Impact factor: 6.998
Authors: Beben Benyamin; Manuel A R Ferreira; Gonneke Willemsen; Scott Gordon; Rita P S Middelberg; Brian P McEvoy; Jouke-Jan Hottenga; Anjali K Henders; Megan J Campbell; Leanne Wallace; Ian H Frazer; Andrew C Heath; Eco J C de Geus; Dale R Nyholt; Peter M Visscher; Brenda W Penninx; Dorret I Boomsma; Nicholas G Martin; Grant W Montgomery; John B Whitfield Journal: Nat Genet Date: 2009-10-11 Impact factor: 38.330
Authors: Andreas Stribolt Rigas; Cecilie Juul Sørensen; Ole Birger Pedersen; Mikkel Steen Petersen; Lise Wegner Thørner; Sebastian Kotzé; Erik Sørensen; Karin Magnussen; Klaus Rostgaard; Christian Erikstrup; Henrik Ullum Journal: Transfusion Date: 2013-12-23 Impact factor: 3.157
Authors: Alan E Mast; John C Langer; Yuelong Guo; Walter Bialkowski; Bryan R Spencer; Tzong-Hae Lee; Joseph Kiss; Ritchard G Cable; Donald Brambilla; Michael P Busch; Grier P Page Journal: Transfusion Date: 2020-03-12 Impact factor: 3.157
Authors: Shangru Lyu; Hong Xing; Mark P DeAndrade; Pablo D Perez; Fumiaki Yokoi; Marcelo Febo; Arthur S Walters; Yuqing Li Journal: Neuroscience Date: 2020-05-22 Impact factor: 3.590
Authors: Hong Zhang; Weili Wang; Wenhu Pi; Nan Bi; Colleen DesRosiers; Fengchong Kong; Monica Cheng; Li Yang; Tim Lautenschlaeger; Shruti Jolly; Jianyue Jin; Feng-Ming Spring Kong Journal: Front Oncol Date: 2021-07-07 Impact factor: 6.244