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Literature DB >> 28149885

Potential biomarkers for radiosensitivity in head and neck cancers.

Sherly Pardo-Reoyo¹, J L Roig-Lopez², Eddy S Yang².

Abstract

Radiotherapy is a mainstay of treatment for head and neck cancer. However, the morbidity of treatment remains a clinical challenge. Molecular profiling has provided further insight into tumor biology and tumor sensitivity to radiation, and this information could be used to personalize treatment. In this review, we discuss published signatures of radiosensitivity and discuss the pathways that may be important in dictating radiation sensitivity. Applications of these signatures could result in less morbidity if dose de-escalation efforts are successful.

Entities: Disease

Keywords: Head and neck cancer; biomarkers; epithelial-mesenchymal transition (EMT); microRNA; radiation sensitivity

Year: 2016 PMID： 28149885 PMCID： PMC5233482 DOI： 10.21037/atm.2016.12.45

Source DB: PubMed Journal: Ann Transl Med ISSN： 2305-5839

33 in total

1. The relationship between EMT, CD44^high /EGFR^low phenotype, and treatment response in head and neck cancer cell lines.

Authors: Ann-Charlotte Johansson; Linnea La Fleur; Styliani Melissaridou; Karin Roberg
Journal: J Oral Pathol Med Date: 2016-01-12 Impact factor: 4.253

2. Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer.

Authors: Gennadi V Glinsky; Olga Berezovska; Anna B Glinskii
Journal: J Clin Invest Date: 2005-06 Impact factor: 14.808

3. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers.

Authors: George Adrian Calin; Cinzia Sevignani; Calin Dan Dumitru; Terry Hyslop; Evan Noch; Sai Yendamuri; Masayoshi Shimizu; Sashi Rattan; Florencia Bullrich; Massimo Negrini; Carlo M Croce
Journal: Proc Natl Acad Sci U S A Date: 2004-02-18 Impact factor: 11.205

4. AURKA promotes cell migration and invasion of head and neck squamous cell carcinoma through regulation of the AURKA/Akt/FAK signaling pathway.

Authors: Jichang Wu; Liyun Yang; Yamin Shan; Changping Cai; Shili Wang; Hao Zhang
Journal: Oncol Lett Date: 2016-01-14 Impact factor: 2.967

5. Validation of a radiosensitivity molecular signature in breast cancer.

Authors: Steven A Eschrich; William J Fulp; Yudi Pawitan; John A Foekens; Marcel Smid; John W M Martens; Michelle Echevarria; Vidya Kamath; Ji-Hyun Lee; Eleanor E Harris; Jonas Bergh; Javier F Torres-Roca
Journal: Clin Cancer Res Date: 2012-07-25 Impact factor: 12.531

Review 6. The basics of epithelial-mesenchymal transition.

Authors: Raghu Kalluri; Robert A Weinberg
Journal: J Clin Invest Date: 2009-06 Impact factor: 14.808

7. Frequency and prognostic significance of p16(INK4A) protein overexpression and transcriptionally active human papillomavirus infection in laryngeal squamous cell carcinoma.

Authors: R J Young; D Urban; C Angel; J Corry; B Lyons; N Vallance; S Kleid; T A Iseli; B Solomon; D Rischin
Journal: Br J Cancer Date: 2015-03-17 Impact factor: 7.640

8. MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways.

Authors: I Fukumoto; T Hanazawa; T Kinoshita; N Kikkawa; K Koshizuka; Y Goto; R Nishikawa; T Chiyomaru; H Enokida; M Nakagawa; Y Okamoto; N Seki
Journal: Br J Cancer Date: 2015-02-10 Impact factor: 7.640

Potential biomarkers for radiosensitivity in head and neck cancers.

1. The relationship between EMT, CD44^high /EGFR^low phenotype, and treatment response in head and neck cancer cell lines.

2. Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer.

3. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers.

4. AURKA promotes cell migration and invasion of head and neck squamous cell carcinoma through regulation of the AURKA/Akt/FAK signaling pathway.

5. Validation of a radiosensitivity molecular signature in breast cancer.

Review 6. The basics of epithelial-mesenchymal transition.

7. Frequency and prognostic significance of p16(INK4A) protein overexpression and transcriptionally active human papillomavirus infection in laryngeal squamous cell carcinoma.

8. MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways.

9. Distinctive pattern of let-7 family microRNAs in aggressive carcinoma of the oral tongue in young patients.

Review 10. miRNAs Signature in Head and Neck Squamous Cell Carcinoma Metastasis: A Literature Review.

1. Mechanisms of different response to ionizing irradiation in isogenic head and neck cancer cell lines.

Review 2. Micro-RNAs, the Cornerstones of the Future of Radiobiology in Head and Neck Cancers?

3. Impact of delays in radiotherapy of head and neck cancer on outcome.