Yongpeng Zou1, Xingtao Huang1, Linxing Feng1, Jingbo Hou1, Lei Xing1, Bo Yu1. 1. Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin 150086, China.
Abstract
BACKGROUND: In-stent neoatherosclerosis (ISNA) is a final common pathway of late-stent failure. However, distribution of ISNA has been little reported. This study was to evaluate the localization of ISNA in relation to curvatures and bifurcations after stent implantation using optical coherence tomography (OCT). METHODS: We retrospectively selected patients who underwent OCT examination ≥12 months after stent (sirolimus-eluting stents, SES) implantation. A stent curvature was defined if the angulation of the stent segment was >29°. Distribution of ISNA in relation to stent curvature and bifurcation was evaluated. RESULTS: Totally, 331 patients were enrolled. The mean follow-up time was 15 months. Forty-one (12.3%) patients were found with ISNA. OCT results showed that stents with ISNA had thicker neointima (mean neointima thickness: 0.16 vs. 0.08 mm, P<0.001) compared to patients without ISNA. Segments with angulation >29° had a higher prevalence of ISNA compared with to angulation ≤29° [18 (18.4%) vs. 23 (9.9%), P=0.032]. ISNA was more frequently located at the "inner curvature" than the "outer curvature" (77.8% vs. 22.2%, P=0.018). If ISNA occurred in a branch, it was more often on the opposite side of the branch compared with the same side of the branch [21 (77.8%) vs. 6 (22.2%), P=0.004]. CONCLUSIONS: Localization of ISNA is related to vessel curvatures and bifurcations. ISNA occurs more often on the inner curvature and the opposite side of the branch.
BACKGROUND: In-stent neoatherosclerosis (ISNA) is a final common pathway of late-stent failure. However, distribution of ISNA has been little reported. This study was to evaluate the localization of ISNA in relation to curvatures and bifurcations after stent implantation using optical coherence tomography (OCT). METHODS: We retrospectively selected patients who underwent OCT examination ≥12 months after stent (sirolimus-eluting stents, SES) implantation. A stent curvature was defined if the angulation of the stent segment was >29°. Distribution of ISNA in relation to stent curvature and bifurcation was evaluated. RESULTS: Totally, 331 patients were enrolled. The mean follow-up time was 15 months. Forty-one (12.3%) patients were found with ISNA. OCT results showed that stents with ISNA had thicker neointima (mean neointima thickness: 0.16 vs. 0.08 mm, P<0.001) compared to patients without ISNA. Segments with angulation >29° had a higher prevalence of ISNA compared with to angulation ≤29° [18 (18.4%) vs. 23 (9.9%), P=0.032]. ISNA was more frequently located at the "inner curvature" than the "outer curvature" (77.8% vs. 22.2%, P=0.018). If ISNA occurred in a branch, it was more often on the opposite side of the branch compared with the same side of the branch [21 (77.8%) vs. 6 (22.2%), P=0.004]. CONCLUSIONS: Localization of ISNA is related to vessel curvatures and bifurcations. ISNA occurs more often on the inner curvature and the opposite side of the branch.
Authors: Ziad A Ali; Tomasz Roleder; Jagat Narula; Bibhu D Mohanty; Usman Baber; Jason C Kovacic; Gary S Mintz; Fumiyuki Otsuka; Stephen Pan; Renu Virmani; Samin K Sharma; Pedro Moreno; Annapoorna S Kini Journal: Circ Cardiovasc Interv Date: 2013-09-24 Impact factor: 6.546
Authors: Christos V Bourantas; Michail I Papafaklis; Anna Kotsia; Vasim Farooq; Takashi Muramatsu; Josep Gomez-Lara; Yao-Jun Zhang; Javaid Iqbal; Fanis G Kalatzis; Katerina K Naka; Dimitrios I Fotiadis; Cecile Dorange; Jin Wang; Richard Rapoza; Hector M Garcia-Garcia; Yoshinobu Onuma; Lampros K Michalis; Patrick W Serruys Journal: JACC Cardiovasc Interv Date: 2014-02-13 Impact factor: 11.195