Kentaro Noda1,2, Ken Yoshida3,4, Taro Ukichi3,4, Kazuhiro Furuya3,4, Kenichiro Hirai3,4, Isamu Kingetsu3,4, Daitaro Kurosaka3,4. 1. From the Division of Rheumatology, Department of Internal Medicine, the Jikei University School of Medicine, Tokyo, Japan. knoda3353@jikei.ac.jp. 2. K. Noda, MD, PhD; K. Yoshida, MD, PhD; T. Ukichi, MD; K. Furuya, MD, PhD; K. Hirai, MD, PhD; I. Kingetsu, MD, PhD; D. Kurosaka, MD, PhD, Division of Rheumatology, Department of Internal Medicine, the Jikei University School of Medicine. knoda3353@jikei.ac.jp. 3. From the Division of Rheumatology, Department of Internal Medicine, the Jikei University School of Medicine, Tokyo, Japan. 4. K. Noda, MD, PhD; K. Yoshida, MD, PhD; T. Ukichi, MD; K. Furuya, MD, PhD; K. Hirai, MD, PhD; I. Kingetsu, MD, PhD; D. Kurosaka, MD, PhD, Division of Rheumatology, Department of Internal Medicine, the Jikei University School of Medicine.
Abstract
OBJECTIVE: To determine the association between fasciitis and the clinical variables in patients with dermatomyositis (DM) and polymyositis (PM). METHODS: We retrospectively reviewed the medical records of 32 patients (24 DM, 8 PM) with newly diagnosed DM and PM and in whom fascia and muscle specimens were histopathologically examined. The relationship between fasciitis and the clinical variables was statistically analyzed. These included age, sex, myalgia, muscle weakness, creatine kinase (CK) and aldolase activities, anti-Jo1 antibody, interstitial lung disease, and malignancy. RESULTS: Twenty (62.5%) of the 32 patients who underwent the histopathological examination of a fascia specimen had fasciitis, including 18 (75%) of 24 patients with DM and 2 (25%) of 8 patients with PM. The frequency of fasciitis was significantly higher among the patients with DM than among the patients with PM (p < 0.05). Histopathologically, fasciitis in PM was very mild in comparison to that in DM. The frequency of myalgia in patients with fasciitis was significantly higher than that in patients without fasciitis (p < 0.05). However, myalgia was not associated with myositis. There were no significant differences in the patients with and without fasciitis in age, sex, manual muscle test 8 scores, CK or aldolase activities, or the presence of anti-Jo1 antibodies and malignancy. CONCLUSION: The frequency of fasciitis was significantly higher among patients with DM than among those with PM. Fasciitis, rather than myositis, was associated with myalgia.
OBJECTIVE: To determine the association between fasciitis and the clinical variables in patients with dermatomyositis (DM) and polymyositis (PM). METHODS: We retrospectively reviewed the medical records of 32 patients (24 DM, 8 PM) with newly diagnosed DM and PM and in whom fascia and muscle specimens were histopathologically examined. The relationship between fasciitis and the clinical variables was statistically analyzed. These included age, sex, myalgia, muscle weakness, creatine kinase (CK) and aldolase activities, anti-Jo1 antibody, interstitial lung disease, and malignancy. RESULTS: Twenty (62.5%) of the 32 patients who underwent the histopathological examination of a fascia specimen had fasciitis, including 18 (75%) of 24 patients with DM and 2 (25%) of 8 patients with PM. The frequency of fasciitis was significantly higher among the patients with DM than among the patients with PM (p < 0.05). Histopathologically, fasciitis in PM was very mild in comparison to that in DM. The frequency of myalgia in patients with fasciitis was significantly higher than that in patients without fasciitis (p < 0.05). However, myalgia was not associated with myositis. There were no significant differences in the patients with and without fasciitis in age, sex, manual muscle test 8 scores, CK or aldolase activities, or the presence of anti-Jo1 antibodies and malignancy. CONCLUSION: The frequency of fasciitis was significantly higher among patients with DM than among those with PM. Fasciitis, rather than myositis, was associated with myalgia.