Hassan Ghasemi1. 1. a Department of Ophthalmology , Shahed University , Tehran , Iran.
Abstract
PURPOSE: This review represents the current in vitro, in vivo animal and human researches on the roles of IL-6 in inflammatory ocular disorders. Data sources were literature reviewed using PubMed, Medline, and ISI Databases (since 1981 to late 2016). Search items included interleukine-6 (IL-6); chemokine; cytokine, alone or in combination with serum, aqueous, vitreous, eye, ocular, ophthalmic, and review. RESULTS: IL-6 is found to be involved in ocular inflammation. Ocular effects of IL-6 differ based on the source of the secretion and site of the action. The most important effects of IL-6 in the eyes are angiogenic activities and induction of ocular inflammation. CONCLUSION: IL-6 plays an important role in ocular inflammation and angiogenesis in conjunctiva, cornea, iris, retina, and orbit. Anti-IL-6 targeted immunotherapy has recently been employed as an important treatment modality in IL-6-related ocular disorders, provided that IL-6 signal blocking takes place in preferred and favorite targets.
PURPOSE: This review represents the current in vitro, in vivo animal and human researches on the roles of IL-6 in inflammatory ocular disorders. Data sources were literature reviewed using PubMed, Medline, and ISI Databases (since 1981 to late 2016). Search items included interleukine-6 (IL-6); chemokine; cytokine, alone or in combination with serum, aqueous, vitreous, eye, ocular, ophthalmic, and review. RESULTS: IL-6 is found to be involved in ocular inflammation. Ocular effects of IL-6 differ based on the source of the secretion and site of the action. The most important effects of IL-6 in the eyes are angiogenic activities and induction of ocular inflammation. CONCLUSION: IL-6 plays an important role in ocular inflammation and angiogenesis in conjunctiva, cornea, iris, retina, and orbit. Anti-IL-6 targeted immunotherapy has recently been employed as an important treatment modality in IL-6-related ocular disorders, provided that IL-6 signal blocking takes place in preferred and favorite targets.
Authors: Junyi Wang; Andrea E Calvert; Nihal Kaplan; Kaylin M McMahon; Wending Yang; Kurt Q Lu; Han Peng; C Shad Thaxton; Robert M Lavker Journal: Adv Ther (Weinh) Date: 2020-09-30
Authors: Oksana Kutsyr; Agustina Noailles; Natalia Martínez-Gil; Lucía Maestre-Carballa; Manuel Martinez-Garcia; Victoria Maneu; Nicolás Cuenca; Pedro Lax Journal: Proc Natl Acad Sci U S A Date: 2021-10-26 Impact factor: 11.205