Literature DB >> 28146351

Implantable Tin Porphyrin-PEG Hydrogels with pH-Responsive Fluorescence.

Haoyuan Huang1, Saurabh Chauhan1, Jumin Geng1, Yiru Qin1, David F Watson1, Jonathan F Lovell1.   

Abstract

Tetracarboxy porphyrins can be polymerized with polyethylene glycol (PEG) diamines to generate hydrogels with intense, near-infrared, and transdermal fluorescence following subcutaneous implantation. Here, we show that the high density porphyrins of the preformed polymer can be chelated with tin via simple incubation. Tin porphyrin hydrogels exhibited increasing emission intensities, ratios, and lifetimes from pH 1 to 10. Tin porphyrin hydrogel emission was strongly reversible and pH responsiveness was observed in the physiological range between pH 6 and pH 8. pH-sensitive emission was detected via noninvasive transdermal fluorescence imaging in vivo following subcutaneous implantation in mice.

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Year:  2017        PMID： 28146351      PMCID： PMC6232081          DOI： 10.1021/acs.biomac.6b01715

Source DB:  PubMed          Journal:  Biomacromolecules        ISSN： 1525-7797            Impact factor:   6.988


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