Literature DB >> 28145721

Isolation and Total Synthesis of Hoshinolactam, an Antitrypanosomal Lactam from a Marine Cyanobacterium.

Hidetoshi Ogawa1, Arihiro Iwasaki1, Shimpei Sumimoto1, Masato Iwatsuki2, Aki Ishiyama2, Rei Hokari2, Kazuhiko Otoguro2, Satoshi O Mura2, Kiyotake Suenaga1.   

Abstract

In the search for new antiprotozoal substances, hoshinolactam, an antitrypanosomal lactam, was isolated from a marine cyanobacterium. The gross structure was elucidated by spectroscopic analyses, and the absolute configuration was determined by the first total synthesis. Hoshinolactam showed potent antitrypanosomal activity with an IC50 value of 3.9 nM without cytotoxicity against human fetal lung fibroblast MRC-5 cells (IC50 > 25 μM).

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Year:  2017        PMID： 28145721     DOI： 10.1021/acs.orglett.7b00047

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  8 in total

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Review 2.  Cyanobacteria-From the Oceans to the Potential Biotechnological and Biomedical Applications.

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Journal:  Mar Drugs       Date:  2021-04-24       Impact factor: 5.118

Review 3.  Structural Diversity, Biological Properties and Applications of Natural Products from Cyanobacteria. A Review.

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Journal:  Mar Drugs       Date:  2017-11-10       Impact factor: 5.118

4.  Three New Malyngamides from the Marine Cyanobacterium Moorea producens.

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Journal:  Mar Drugs       Date:  2017-11-29       Impact factor: 5.118

Review 5.  The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms.

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Journal:  Mar Drugs       Date:  2020-02-15       Impact factor: 5.118

Review 6.  Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles.

Authors:  Justus Amuche Nweze; Florence N Mbaoji; Yan-Ming Li; Li-Yan Yang; Shu-Shi Huang; Vincent N Chigor; Emmanuel A Eze; Li-Xia Pan; Ting Zhang; Deng-Feng Yang
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7.  Total Synthesis and Anti-Inflammatory Bioactivity of (-)-Majusculoic Acid and Its Derivatives.

Authors:  Hong-Xiu Xiao; Qing-Xiang Yan; Zhi-Hui He; Zheng-Biao Zou; Qing-Qing Le; Ting-Ting Chen; Bing Cai; Xian-Wen Yang; Su-Lan Luo
Journal:  Mar Drugs       Date:  2021-05-21       Impact factor: 5.118

8.  Asymmetric and Site-Selective [3 + 2]-Annulations for the Synthesis of High-Value Bicyclic Lactams.

Authors:  Dimitris Kalaitzakis; Manolis Sofiadis; Myron Triantafyllakis; Konstantinos Daskalakis; Georgios Vassilikogiannakis
Journal:  Org Lett       Date:  2018-02-08       Impact factor: 6.005
  8 in total

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