Xiao-Quan Xu1, Chen-Jiang Wu1, Qing-Quan Zu1, Shan-Shan Lu1, Xing-Long Liu1, Qian-Qian Gao1, Sheng Liu2, Hai-Bin Shi3. 1. Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, No. 300, Guangzhou Rd., Nanjing, China. 2. Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, No. 300, Guangzhou Rd., Nanjing, China. liusheng@njmu.edu.cn. 3. Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, No. 300, Guangzhou Rd., Nanjing, China. shihb@njmu.edu.cn.
Abstract
BACKGROUND: To assess the influence of the hyperintense acute reperfusion marker (HARM) on the relative signal intensity (rSI) and apparent diffusion coefficient (ADC) of hyper-acute ischemic lesions in a canine stroke model. METHODS: Middle cerebral artery occlusion models were established using autologous clot embolization. Diffusion-weighted (DW) and fluid-attenuated inversion recovery (FLAIR) imaging was performed at 1, 2, 3, 4.5 and 6 h after embolization. HARM was defined as the delayed enhancement of cerebrospinal fluid on the subsequent FLAIR images after contrast media used. RESULTS: Twenty-four stroke models were successfully established and divided into the HARM (n = 16) and No-HARM group (n = 8). No significant differences were found in the rSI on DWI (b0 and b1000 map) and relative ADC between the two groups at each time point after embolization (all P > 0.05). There were no significant differences in the rSI on FLAIR at 1 and 2 h after embolization between the two groups (P > 0.05), while the HARM group showed significantly higher rSI on FLAIR than the No-HARM group at 3, 4.5 and 6 h after embolization (P = 0.044, 0.036 and 0.001, respectively). CONCLUSIONS: HARM should be noted during the quantitative analysis of FLAIR images in future clinical practice.
BACKGROUND: To assess the influence of the hyperintense acute reperfusion marker (HARM) on the relative signal intensity (rSI) and apparent diffusion coefficient (ADC) of hyper-acute ischemic lesions in a caninestroke model. METHODS:Middle cerebral artery occlusion models were established using autologous clot embolization. Diffusion-weighted (DW) and fluid-attenuated inversion recovery (FLAIR) imaging was performed at 1, 2, 3, 4.5 and 6 h after embolization. HARM was defined as the delayed enhancement of cerebrospinal fluid on the subsequent FLAIR images after contrast media used. RESULTS: Twenty-four stroke models were successfully established and divided into the HARM (n = 16) and No-HARM group (n = 8). No significant differences were found in the rSI on DWI (b0 and b1000 map) and relative ADC between the two groups at each time point after embolization (all P > 0.05). There were no significant differences in the rSI on FLAIR at 1 and 2 h after embolization between the two groups (P > 0.05), while the HARM group showed significantly higher rSI on FLAIR than the No-HARM group at 3, 4.5 and 6 h after embolization (P = 0.044, 0.036 and 0.001, respectively). CONCLUSIONS: HARM should be noted during the quantitative analysis of FLAIR images in future clinical practice.
Authors: Vince Istvan Madai; Carla N Wood; Ivana Galinovic; Ulrike Grittner; Sophie K Piper; Gajanan S Revankar; Steve Z Martin; Olivier Zaro-Weber; Walter Moeller-Hartmann; Federico C von Samson-Himmelstjerna; Wolf-Dieter Heiss; Martin Ebinger; Jochen B Fiebach; Jan Sobesky Journal: Cerebrovasc Dis Date: 2016-03-18 Impact factor: 2.762
Authors: Götz Thomalla; Bastian Cheng; Martin Ebinger; Qing Hao; Thomas Tourdias; Ona Wu; Jong S Kim; Lorenz Breuer; Oliver C Singer; Steven Warach; Soren Christensen; Andras Treszl; Nils D Forkert; Ivana Galinovic; Michael Rosenkranz; Tobias Engelhorn; Martin Köhrmann; Matthias Endres; Dong-Wha Kang; Vincent Dousset; A Gregory Sorensen; David S Liebeskind; Jochen B Fiebach; Jens Fiehler; Christian Gerloff Journal: Lancet Neurol Date: 2011-10-04 Impact factor: 44.182