Literature DB >> 28144828

Physiological expression of pancreatic somatostatin receptors in 99mTc-HYNIC-TOC scintigraphy.

L de la Cueva1, P Lloro2, M J Sangrós2, L López Vélez3, P Navarro2, L Sarria4, S Álvarez2, D Abós2.   

Abstract

PURPOSE: To describe the frequency of head and/or pancreas uncinate process uptake of 99mTc-HYNIC-TOC, to study its nature, and analyze its diagnostic value.
MATERIALS AND METHODS: Retrospective evaluation of 47 consecutive 99mTc-HYNIC-TOC examinations was conducted. Head and/or pancreas uncinate process uptake was considered to be physiological in patients with normal CT at the same episode and in follow-up. It was analyzed if age or diabetes mellitus was justifying the existence or not of uptake.
RESULTS: 32.5% patients showed uptake; 73% of them were mild. 84.6% patients with uptake have no pathology and 4% had neuroendocrine pancreatic disease at CT. Neither the age nor the diabetes mellitus established differences in patients without lesion.
CONCLUSIONS: Near one-third of patients show physiological uptake by head and/or pancreas uncinate process at 99mTc-HYNIC-TOC scintigraphy. It seems that neither the diabetes nor the ages are factors that determine this physiological uptake.

Entities:  

Keywords:  99mTc-HYNIC-TOC; Neuroendocrine tumors; Pancreas uncinate process; Somatostatin receptor scintigraphy

Mesh:

Substances:

Year:  2017        PMID: 28144828     DOI: 10.1007/s12094-017-1616-3

Source DB:  PubMed          Journal:  Clin Transl Oncol        ISSN: 1699-048X            Impact factor:   3.405


  27 in total

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2.  Procedure guidelines for PET/CT tumour imaging with 68Ga-DOTA-conjugated peptides: 68Ga-DOTA-TOC, 68Ga-DOTA-NOC, 68Ga-DOTA-TATE.

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Journal:  Eur J Nucl Med Mol Imaging       Date:  2010-10       Impact factor: 9.236

3.  68Ga-DOTA-TOC uptake in neuroendocrine tumour and healthy tissue: differentiation of physiological uptake and pathological processes in PET/CT.

Authors:  A Kroiss; D Putzer; C Decristoforo; C Uprimny; B Warwitz; B Nilica; M Gabriel; D Kendler; D Waitz; G Widmann; I J Virgolini
Journal:  Eur J Nucl Med Mol Imaging       Date:  2013-01-05       Impact factor: 9.236

4.  Semiquantitative analysis and characterization of physiological biodistribution of (68)Ga-DOTA-TATE PET/CT.

Authors:  Jolanta Kunikowska; Leszek Królicki; Dariusz Pawlak; Imene Zerizer; Renata Mikołajczak
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5.  Biodistribution of the Ga-68 labeled somatostatin analogue DOTA-NOC in patients with neuroendocrine tumors: characterization of uptake in normal organs and tumor lesions.

Authors:  V Prasad; R P Baum
Journal:  Q J Nucl Med Mol Imaging       Date:  2010-02       Impact factor: 2.346

Review 6.  Role of somatostatins in gastroenteropancreatic neuroendocrine tumor development and therapy.

Authors:  Kjell E Oberg; Jean-Claude Reubi; Dik J Kwekkeboom; Eric P Krenning
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7.  Somatostatin receptor imaging with 68Ga DOTATATE PET/CT: clinical utility, normal patterns, pearls, and pitfalls in interpretation.

Authors:  Michael S Hofman; W F Eddie Lau; Rodney J Hicks
Journal:  Radiographics       Date:  2015 Mar-Apr       Impact factor: 5.333

Review 8.  Cancer of the uncinate process of the pancreas: surgical anatomy and clinicopathological features.

Authors:  Adrian W O'Sullivan; Nigel Heaton; Mohamed Rela
Journal:  Hepatobiliary Pancreat Dis Int       Date:  2009-12

9.  An intrapatient comparison of 99mTc-EDDA/HYNIC-TOC with 111In-DTPA-octreotide for diagnosis of somatostatin receptor-expressing tumors.

Authors:  Michael Gabriel; Clemens Decristoforo; Eveline Donnemiller; Hanno Ulmer; Christine Watfah Rychlinski; Stephen J Mather; Roy Moncayo
Journal:  J Nucl Med       Date:  2003-05       Impact factor: 10.057

10.  Positron emission tomography study on pancreatic somatostatin receptors in normal and diabetic rats with 68Ga-DOTA-octreotide: a potential PET tracer for beta cell mass measurement.

Authors:  Takeo Sako; Koki Hasegawa; Mie Nishimura; Yousuke Kanayama; Yasuhiro Wada; Emi Hayashinaka; Yilong Cui; Yosky Kataoka; Michio Senda; Yasuyoshi Watanabe
Journal:  Biochem Biophys Res Commun       Date:  2013-11-09       Impact factor: 3.575

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  1 in total

1.  [68Ga]Ga-DOTANOC Uptake at Pancreatic Head/Uncinate Process: Is It a Persistent Diagnostic Pitfall Over Time?

Authors:  Elena Tabacchi; Emilia Fortunati; Giulia Argalia; Lucia Zanoni; Diletta Calabrò; Silvi Telo; Davide Campana; Giuseppe Lamberti; Claudio Ricci; Riccardo Casadei; Stefano Fanti; Valentina Ambrosini
Journal:  Cancers (Basel)       Date:  2022-07-21       Impact factor: 6.575

  1 in total

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