| Literature DB >> 28143704 |
A A Hamid1, Tanu Kaushal2, Raghib Ashraf3, Arjun Singh2, Amit Chand Gupta2, Om Prakash2, Jayanta Sarkar3, Debabrata Chanda2, D U Bawankule2, Feroz Khan2, Karuna Shanker2, O O Aiyelaagbe4, Arvind S Negi5.
Abstract
Prostate cancer is one of the most common cancers in men. Diosgenin and related compounds are potential cytotoxic agents. Twelve diverse analogues of long chain fatty acid/ester of diosgenin-7-ketoxime have been prepared. Six of the analogues exhibited significant anticancer activity against a panel of human cancer cell lines with IC50 ranging from 12 to 35μM. Compound 16, the best representative of the series exerted S phase arrest in DU145 prostate cancer cells and induced apoptosis through caspase pathway. Additionally, these analogues inhibited lipopolysaccharide induced pro-inflammatory cytokines (TNF-α and IL-6) up to 47.7% and 23.3% respectively. Compound 16 was found to be safe in acute oral toxicity in Swiss albino mice up to 300mg/kg dose. The anticancer and antiinflammatory properties of compound 16 are important and can further be optimized for a better anti-prostate cancer candidate.Entities:
Keywords: Acute oral toxicity; Anticancer; Antiinflammatory; Caspase pathway; Diosgenin; Oxime derivatives
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Year: 2017 PMID： 28143704 DOI： 10.1016/j.steroids.2017.01.001
Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668