Anna Posod1, Susanne Müller1, Irena Odri Komazec1,2, Daniel Dejaco3, Ulrike Pupp Peglow1, Elke Griesmaier1, Sabine Scholl-Bürgi4, Daniela Karall4, Ursula Kiechl-Kohlendorfer1. 1. Pediatrics II (Neonatology), Department of Pediatrics, Medical University of Innsbruck, Innsbruck, Austria. 2. Pediatrics III (Pediatric Cardiology), Department of Pediatrics, Medical University of Innsbruck, Innsbruck, Austria. 3. Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria. 4. Pediatrics I (Inherited Metabolic Disorders), Department of Pediatrics, Medical University of Innsbruck, Innsbruck, Austria.
Abstract
BACKGROUND: Amino acid analysis is a valuable tool for cardiovascular risk assessment. Preterm infants display plasma amino acid changes in the newborn period. Whether these changes persist is unknown to date. The aim of this study was to assess whether former very preterm infants (VPI) show alterations in amino acid patterns indicative of an unfavorable cardiovascular risk profile at a preschool age. METHODS: From 5-7 y-old children born at term or <32 wk gestation (VPI) were included in the study. Plasma amino acid concentrations were determined after an overnight fast. RESULTS: 29 former term infants and 79 former VPI were included in the study. Former VPI showed changes in various plasma amino acids including glutamine, arginine, citrulline, tryptophan, glutamate, ornithine, and taurine. Branched-chain amino acids were lower, alanine/lysine ratios significantly higher in the preterm population. CONCLUSION: Former VPI show altered plasma amino acid profiles indicative of a dualistic cardiovascular risk profile (e.g., potentially beneficial elevations in citrulline, arginine, glutamine, and tryptophan, but also raised alanine/lysine ratios, low ornithine and taurine levels) at a preschool age. Whether this is associated with an adverse cardiovascular outcome has to be addressed by future studies. Long-term cardiometabolic follow-up of VPI might be warranted.
BACKGROUND: Amino acid analysis is a valuable tool for cardiovascular risk assessment. Preterm infants display plasma amino acid changes in the newborn period. Whether these changes persist is unknown to date. The aim of this study was to assess whether former very preterm infants (VPI) show alterations in amino acid patterns indicative of an unfavorable cardiovascular risk profile at a preschool age. METHODS: From 5-7 y-old children born at term or <32 wk gestation (VPI) were included in the study. Plasma amino acid concentrations were determined after an overnight fast. RESULTS: 29 former term infants and 79 former VPI were included in the study. Former VPI showed changes in various plasma amino acids including glutamine, arginine, citrulline, tryptophan, glutamate, ornithine, and taurine. Branched-chain amino acids were lower, alanine/lysine ratios significantly higher in the preterm population. CONCLUSION: Former VPI show altered plasma amino acid profiles indicative of a dualistic cardiovascular risk profile (e.g., potentially beneficial elevations in citrulline, arginine, glutamine, and tryptophan, but also raised alanine/lysine ratios, low ornithine and taurine levels) at a preschool age. Whether this is associated with an adverse cardiovascular outcome has to be addressed by future studies. Long-term cardiometabolic follow-up of VPI might be warranted.
Authors: Anna Posod; Irena Odri Komazec; Ulrike Pupp Peglow; Dagmar Meraner; Elke Griesmaier; Ursula Kiechl-Kohlendorfer Journal: Biomed Res Int Date: 2017-07-19 Impact factor: 3.411
Authors: Anna Posod; Raimund Pechlaner; Xiaoke Yin; Sean Anthony Burnap; Sophia Julia Kiechl; Johann Willeit; Joseph L Witztum; Manuel Mayr; Stefan Kiechl; Ursula Kiechl-Kohlendorfer Journal: J Am Heart Assoc Date: 2019-04-16 Impact factor: 5.501
Authors: Thilini N Jayasinghe; Tommi Vatanen; Valentina Chiavaroli; Sachin Jayan; Elizabeth J McKenzie; Evelien Adriaenssens; José G B Derraik; Cameron Ekblad; William Schierding; Malcolm R Battin; Eric B Thorstensen; David Cameron-Smith; Elizabeth Forbes-Blom; Paul L Hofman; Nicole C Roy; Gerald W Tannock; Mark H Vickers; Wayne S Cutfield; Justin M O'Sullivan Journal: Front Cell Infect Microbiol Date: 2020-06-16 Impact factor: 5.293