Julie Chastang1,2, Nour Baiz1, Laure Parnet1,2, Jean Sébastien Cadwallader2, Frédéric De Blay3, Denis Caillaud4, Denis André Charpin5, John Dwyer1, François Lavaud6, Chantal Raherison7, Gladys Ibanez1,2, Isabella Annesi-Maesano1. 1. Faculté de médecine de l'hôpital Saint-Antoine, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP UMRS 1136 Equipe Epidémiologie des maladies allergiques et respiratoires (EPAR), UPMC Univ Paris 06, Universités Paris Sorbonne, Paris, France. 2. Département de Médecine générale, Faculté de Médecine, Paris UPMC, Université Paris 6, Paris, France. 3. Service de pneumologie, CHU de Strasbourg, Strasbourg, France. 4. Service de pneumologie, CHU de Clermont-Ferrand, Clermont-Ferrand, France. 5. Service de pneumologie, CHU de Marseille, Marseille, France. 6. Service de pneumologie et allergologie, CHU de Reims, Reims, France. 7. Service de pneumologie et affections respiratoires, CHU de Bordeaux, Bordeaux, France.
Abstract
BACKGROUND: It is known that asthma is related to obesity but also to small birthweight. The objective of this study was to clarify this issue by assessing the putative relationship between the changes in corpulence between birth and childhood as assessed by body mass index (BMI) and asthma phenotypes. METHODS: The following status in corpulence was assessed in 7781 schoolchildren using quartile of BMI at birth and at around 10 (9-11 years): underweight at birth and at around 10, underweight at birth and overweight at around 10, overweight at birth and underweight at around 10, overweight at birth and at around 10, and the reference group constituted by all the other children in whom corpulence changes were not extreme. Determination of asthma phenotypes (allergic, non-allergic, and exercise-induced asthma) was based on a clinical examination including skin prick tests, an exercise challenge test, and a questionnaire. RESULTS: The risk of allergic asthma was higher in children with persistent underweight, children with persistent overweight, and children becoming markedly more corpulent. In boys, the risk of allergic asthma was significantly higher for the less corpulent children at birth, regardless of whether they remained so or become overweight. In girls, the risk of allergic asthma was significantly higher in those with persistent overweight. There were no significant associations between BMI changes and non-allergic and exercise-induced asthma. CONCLUSIONS: We observed that some extreme changes in BMI, persistent underweight, and persistent overweight in childhood increased the risk of allergic asthma.
BACKGROUND: It is known that asthma is related to obesity but also to small birthweight. The objective of this study was to clarify this issue by assessing the putative relationship between the changes in corpulence between birth and childhood as assessed by body mass index (BMI) and asthma phenotypes. METHODS: The following status in corpulence was assessed in 7781 schoolchildren using quartile of BMI at birth and at around 10 (9-11 years): underweight at birth and at around 10, underweight at birth and overweight at around 10, overweight at birth and underweight at around 10, overweight at birth and at around 10, and the reference group constituted by all the other children in whom corpulence changes were not extreme. Determination of asthma phenotypes (allergic, non-allergic, and exercise-induced asthma) was based on a clinical examination including skin prick tests, an exercise challenge test, and a questionnaire. RESULTS: The risk of allergic asthma was higher in children with persistent underweight, children with persistent overweight, and children becoming markedly more corpulent. In boys, the risk of allergic asthma was significantly higher for the less corpulent children at birth, regardless of whether they remained so or become overweight. In girls, the risk of allergic asthma was significantly higher in those with persistent overweight. There were no significant associations between BMI changes and non-allergic and exercise-induced asthma. CONCLUSIONS: We observed that some extreme changes in BMI, persistent underweight, and persistent overweight in childhood increased the risk of allergic asthma.
Authors: Francisca de Castro Mendes; Inês Paciência; João Cavaleiro Rufo; Diana Silva; Pedro Cunha; Mariana Farraia; Luís Delgado; Pedro Moreira; André Moreira Journal: ERJ Open Res Date: 2019-11-04
Authors: Bronwyn K Brew; Emma Caffrey Osvald; Tong Gong; Anna M Hedman; Kirsten Holmberg; Henrik Larsson; Jonas F Ludvigsson; Mwenya Mubanga; Awad I Smew; Catarina Almqvist Journal: Clin Exp Allergy Date: 2022-07-28 Impact factor: 5.401