Miji Kim1, Takao Suzuki2, Narumi Kojima3, Hideyo Yoshida3, Yuko Yoshida3, Hirohiko Hirano3, Chang Won Won4, Hunkyung Kim3. 1. East-West Medical Research Institute, Kyung Hee University, Seoul, Korea. 2. National Center for Geriatrics and Gerontology, Aichi, Japan. 3. Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan. 4. College of Medicine, Kyung Hee University, Seoul, Korea.
Abstract
OBJECTIVES: To investigate whether higher serum β2 -microglobulin (B2M) levels, a kidney function marker, are associated with prevalent and incident frailty in community-dwelling older women. DESIGN: Cross-sectional and longitudinal analyses of a prospective cohort. SETTING: Population-based cohort study in Tokyo, Japan. PARTICIPANTS: Community-dwelling women aged 75 and older with adequate data for assessing frailty status (N = 1,191) and a subset of participants without baseline frailty but with repeated frailty assessment at 2 and 4 years of follow-up. MEASUREMENTS: The primary predictor was B2M level. Outcomes were prevalent and incident frailty during the 4-year follow-up period. Frailty was defined as presence of three of the five Fried criteria: weight loss, exhaustion, weakness, slowness, and low physical activity. Adjusted odds ratios for the main confounders were obtained using logistic regression. Discrete-time Cox proportional hazards models were used to determine the risk of developing frailty. RESULTS: The study included 241 (20.2%) women with prevalent frailty at baseline and 139 (21.1%) with incident frailty during the 4-year follow-up. On multivariate analysis adjusted for multiple potential confounders, the odds of prevalent frailty were 2.5 times as great with B2M levels of 1.9 to 2.1 mg/L as with levels less than 1.6 mg/L and 2.0 times as great with B2M levels of 2.2 mg/L or more. In the unadjusted model, B2M levels of 1.9 to 2.1 mg/L were associated with a greater incidence of frailty than B2M levels of less than 1.6 mg/L (hazard ratio = 1.72, 95% confidence interval = 1.04-2.86). In the multivariate analysis adjusted for potential confounders, no significant association was noted between the highest B2M quartile and incident frailty. CONCLUSION: Higher B2M levels were independently associated with greater frailty at baseline in older adults but only slightly associated with greater risk of incident frailty over 4 years of follow-up.
OBJECTIVES: To investigate whether higher serum β2 -microglobulin (B2M) levels, a kidney function marker, are associated with prevalent and incident frailty in community-dwelling older women. DESIGN: Cross-sectional and longitudinal analyses of a prospective cohort. SETTING: Population-based cohort study in Tokyo, Japan. PARTICIPANTS: Community-dwelling women aged 75 and older with adequate data for assessing frailty status (N = 1,191) and a subset of participants without baseline frailty but with repeated frailty assessment at 2 and 4 years of follow-up. MEASUREMENTS: The primary predictor was B2M level. Outcomes were prevalent and incident frailty during the 4-year follow-up period. Frailty was defined as presence of three of the five Fried criteria: weight loss, exhaustion, weakness, slowness, and low physical activity. Adjusted odds ratios for the main confounders were obtained using logistic regression. Discrete-time Cox proportional hazards models were used to determine the risk of developing frailty. RESULTS: The study included 241 (20.2%) women with prevalent frailty at baseline and 139 (21.1%) with incident frailty during the 4-year follow-up. On multivariate analysis adjusted for multiple potential confounders, the odds of prevalent frailty were 2.5 times as great with B2M levels of 1.9 to 2.1 mg/L as with levels less than 1.6 mg/L and 2.0 times as great with B2M levels of 2.2 mg/L or more. In the unadjusted model, B2M levels of 1.9 to 2.1 mg/L were associated with a greater incidence of frailty than B2M levels of less than 1.6 mg/L (hazard ratio = 1.72, 95% confidence interval = 1.04-2.86). In the multivariate analysis adjusted for potential confounders, no significant association was noted between the highest B2M quartile and incident frailty. CONCLUSION: Higher B2M levels were independently associated with greater frailty at baseline in older adults but only slightly associated with greater risk of incident frailty over 4 years of follow-up.
Authors: Anna L Höving; Kazuko E Schmidt; Barbara Kaltschmidt; Christian Kaltschmidt; Cornelius Knabbe Journal: Int J Mol Sci Date: 2022-08-25 Impact factor: 6.208
Authors: Richard Ofori-Asenso; Ken L Chin; Mohsen Mazidi; Ella Zomer; Jenni Ilomaki; Andrew R Zullo; Danijela Gasevic; Zanfina Ademi; Maarit J Korhonen; Dina LoGiudice; J Simon Bell; Danny Liew Journal: JAMA Netw Open Date: 2019-08-02