Wei Zheng1, Guo Tong2, Gabor S Ungvari3,4, Chee H Ng5, Helen F K Chiu6, Ying-Qiang Xiang7, Xiao-Lan Cao8,9, Zheng-Rong Liu10, Li-Rong Meng11, Gábor Gazdag12, Yu-Tao Xiang13. 1. Resident Psychiatrist, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China. 2. Resident Psychiatrist, The National Clinical Research Center for Mental Disorders and Beijing Anding Hospital, Capital Medical University, Beijing, China. 3. Professor, School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Australia. 4. The University of Notre Dame Australia/Marian Centre, Perth, Australia. 5. Professor, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia. 6. Professor, Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China. 7. Associate Professor, The National Clinical Research Center for Mental Disorders and Beijing Anding Hospital, Capital Medical University, Beijing, China. 8. Attending Psychiatrist, Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China. 9. Shenzhen Key Laboratory for Psychological Healthcare and Shenzhen Institute of Mental Health, Shenzhen Kangning Hospital and Shenzhen Mental Health Center, Shenzhen, China. 10. Attending Psychiatrist, Mental Hospital of Guangzhou Civil Administration, Guangzhou, China. 11. Professor, School of Health Sciences, Macao Polytechnic Institute, Macao SAR, China. 12. Honorary Associate Professor, Consultation-Liaison Psychiatric Service, Szent Istvan and Szent Laszlo Hospitals, Budapest, Hungary. 13. Associate Professor, Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China.
Abstract
PURPOSE: To evaluate memory impairment associated with electroconvulsive therapy (ECT)-antipsychotic (AP) combination in comparison to AP monotherapy in schizophrenia. DESIGN AND METHODS: A systematic literature search of randomized controlled trial (RCTs) was performed. FINDINGS: Eleven RCTs that compared ECT-AP combination (n = 508) with AP monotherapy (n = 510) were analyzed. ECT-AP combination was associated with greater impairment than AP monotherapy in (1) endpoint memory quotient (MQ) of the Wechsler Memory Scale (WMS)-Revised at the end of the ECT course; and (2) picture recall, counting, recognition, and associative learning of the WMS. However, no group difference was found in MQ at 1 and 2 weeks post-ECT. PRACTICE IMPLICATIONS: The ECT-AP combination was associated with greater transient memory impairment compared to AP monotherapy.
PURPOSE: To evaluate memory impairment associated with electroconvulsive therapy (ECT)-antipsychotic (AP) combination in comparison to AP monotherapy in schizophrenia. DESIGN AND METHODS: A systematic literature search of randomized controlled trial (RCTs) was performed. FINDINGS: Eleven RCTs that compared ECT-AP combination (n = 508) with AP monotherapy (n = 510) were analyzed. ECT-AP combination was associated with greater impairment than AP monotherapy in (1) endpoint memory quotient (MQ) of the Wechsler Memory Scale (WMS)-Revised at the end of the ECT course; and (2) picture recall, counting, recognition, and associative learning of the WMS. However, no group difference was found in MQ at 1 and 2 weeks post-ECT. PRACTICE IMPLICATIONS: The ECT-AP combination was associated with greater transient memory impairment compared to AP monotherapy.