Literature DB >> 28137861

Emergence of function from coordinated cells in a tissue.

Indika Rajapakse1, Stephen Smale2.   

Abstract

This work presents a mathematical study of tissue dynamics. We combine within-cell genome dynamics and diffusion between cells, so that the synthesis of the two gives rise to the emergence of function, akin to establishing "tissue homeostasis." We introduce two concepts, monotonicity and a weak version of hardwiring. These together are sufficient for global convergence of the tissue dynamics.

Keywords:  diffusion; emergence; genome dynamics; monotonicity; tissue dynamics

Mesh:

Year:  2017        PMID: 28137861      PMCID: PMC5321023          DOI: 10.1073/pnas.1621145114

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


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