Literature DB >> 28137420

Aurora Kinase B Phosphorylates Histone H3.3 at Serine 31 during Mitosis in Mammalian Cells.

Miao Li1, Qiang Dong2, Bing Zhu3.   

Abstract

Serine 31 of histone H3.3 is phosphorylated during mitosis in mammalian cells and has been shown to influence chromosome segregation. We established a screening system to identify candidate kinase(s) phosphorylating H3.3S31 by using siRNA library targeting 720 human kinases, and we confirmed the results with an independent kinase inhibitor screen. Aurora kinase B was the best candidate hit in both screens. Moreover, the kinase activity of Aurora B on H3.3S31 was biochemically confirmed with nucleosomal substrates in vitro.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Aurora kinase B; H3.3S31ph; histone phosphorylation; siRNA screen

Mesh：

Substances：

Year:  2017        PMID： 28137420     DOI： 10.1016/j.jmb.2017.01.016

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  9 in total

Review 1.  The Relevance of Aurora Kinase Inhibition in Hematological Malignancies.

Authors:  Caio Bezerra Machado; Emerson Lucena DA Silva; Beatriz Maria Dias Nogueira; Jean Breno Silveira DA Silva; Manoel Odorico DE Moraes Filho; Raquel Carvalho Montenegro; Maria Elisabete Amaral DE Moraes; Caroline Aquino Moreira-Nunes
Journal:  Cancer Diagn Progn       Date:  2021-07-03

Review 2.  Priming chromatin for segregation: functional roles of mitotic histone modifications.

Authors:  M Lienhard Schmitz; Jonathan M G Higgins; Markus Seibert
Journal:  Cell Cycle       Date:  2020-01-28       Impact factor: 4.534

3.  Phosphorylation of histone H3.3 at serine 31 promotes p300 activity and enhancer acetylation.

Authors:  Sara Martire; Aishwarya A Gogate; Amanda Whitmill; Amanuel Tafessu; Jennifer Nguyen; Yu-Ching Teng; Melodi Tastemel; Laura A Banaszynski
Journal:  Nat Genet       Date:  2019-05-31       Impact factor: 38.330

4.  Targeting Chromatin Remodeling for Cancer Therapy.

Authors:  Jasmine Kaur; Abdelkader Daoud; Scott T Eblen
Journal:  Curr Mol Pharmacol       Date:  2019       Impact factor: 3.339

Review 5.  Histone variants at a glance.

Authors:  Paul B Talbert; Steven Henikoff
Journal:  J Cell Sci       Date:  2021-03-26       Impact factor: 5.285

6.  Single-cell RNA-seq uncovered hemocyte functional subtypes and their differentiational characteristics and connectivity with morphological subpopulations in Litopenaeus vannamei.

Authors:  Chuang Cui; Xiaoqian Tang; Jing Xing; Xiuzhen Sheng; Heng Chi; Wenbin Zhan
Journal:  Front Immunol       Date:  2022-09-13       Impact factor: 8.786

7.  Histone H3.3 phosphorylation amplifies stimulation-induced transcription.

Authors:  Anja Armache; Shuang Yang; Alexia Martínez de Paz; Lexi E Robbins; Ceyda Durmaz; Jin Q Cheong; Arjun Ravishankar; Andrew W Daman; Dughan J Ahimovic; Thaís Klevorn; Yuan Yue; Tanja Arslan; Shu Lin; Tanya Panchenko; Joel Hrit; Miao Wang; Samuel Thudium; Benjamin A Garcia; Erica Korb; Karim-Jean Armache; Scott B Rothbart; Sandra B Hake; C David Allis; Haitao Li; Steven Z Josefowicz
Journal:  Nature       Date:  2020-07-22       Impact factor: 49.962

8.  Histone variant H3.3 residue S31 is essential for Xenopus gastrulation regardless of the deposition pathway.

Authors:  David Sitbon; Ekaterina Boyarchuk; Florent Dingli; Damarys Loew; Geneviève Almouzni
Journal:  Nat Commun       Date:  2020-03-09       Impact factor: 14.919

9.  Establishment and function of chromatin modification at enhancers.

Authors:  Amanuel Tafessu; Laura A Banaszynski
Journal:  Open Biol       Date:  2020-10-14       Impact factor: 6.411
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.