Literature DB >> 28137208

C. elegans as Model for Drug Discovery.

Maria Carretero1, Gregory M Solis2, Michael Petrascheck3.   

Abstract

Small molecule screens using C. elegans as a model are becoming increasingly popular as the number of high-throughput methodologies has steadily increased over the years. Here we focus on the biology that underlies this increased popularity and outline the reasons that make C. elegans an attractive model for drug discovery. We discuss successful C. elegans based drug discovery projects in the literature and future challenges ahead. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  C. elegans; Cancer biology; Drug discovery; HTS; Nematodes; Vertebrate vascular endothelial growth factors

Mesh：

Substances：

Year:  2017        PMID： 28137208     DOI： 10.2174/1568026617666170131114401

Source DB:  PubMed          Journal:  Curr Top Med Chem        ISSN： 1568-0266            Impact factor:   3.295


  11 in total

1.  Superoxide Dismutase (SOD) and Catalase (CAT) Activity Assay Protocols for Caenorhabditis elegans.

Authors:  Jing Zhang; Rui Chen; Zhenyang Yu; Lili Xue
Journal:  Bio Protoc       Date:  2017-08-20

2.  Development of a traditional Chinese medicine-based agent for the treatment of cancer cachexia.

Authors:  Kun-Chang Wu; Po-Chen Chu; Yu-Jung Cheng; Chia-Ing Li; Jingkui Tian; Hsing-Yu Wu; Szu-Hsien Wu; Yi-Chun Lai; Hsiang-Han Kao; Ao-Lin Hsu; Hsiang-Wen Lin; Chih-Hsueh Lin
Journal:  J Cachexia Sarcopenia Muscle       Date:  2022-06-19       Impact factor: 12.063

Review 3.  Modeling human brain tumors in flies, worms, and zebrafish: From proof of principle to novel therapeutic targets.

Authors:  Uswa Shahzad; Michael S Taccone; Sachin A Kumar; Hidehiro Okura; Stacey Krumholtz; Joji Ishida; Coco Mine; Kyle Gouveia; Julia Edgar; Christian Smith; Madeline Hayes; Xi Huang; W Brent Derry; Michael D Taylor; James T Rutka
Journal:  Neuro Oncol       Date:  2021-05-05       Impact factor: 12.300

4.  A robust and miniaturized screening platform to study natural products affecting metabolism and survival in Caenorhabditis elegans.

Authors:  Julia Zwirchmayr; Benjamin Kirchweger; Theresa Lehner; Ammar Tahir; Dagmar Pretsch; Judith M Rollinger
Journal:  Sci Rep       Date:  2020-07-23       Impact factor: 4.379

5.  Novel coumarins active against Trypanosoma cruzi and toxicity assessment using the animal model Caenorhabditis elegans.

Authors:  Fabiana Gomes Nascimento Soares; Gabriela Göethel; Luciano Porto Kagami; Gustavo Machado das Neves; Elisa Sauer; Estefania Birriel; Javier Varela; Itamar Luís Gonçalves; Gilsane Von Poser; Mercedes González; Daniel Fábio Kawano; Fávero Reisdorfer Paula; Eduardo Borges de Melo; Solange Cristina Garcia; Hugo Cerecetto; Vera Lucia Eifler-Lima
Journal:  BMC Pharmacol Toxicol       Date:  2019-12-19       Impact factor: 2.483

6.  A novel assay for drug screening that utilizes the heat shock response of Caenorhabditis elegans nematodes.

Authors:  Chih-Hsiung Chen; Rahul Patel; Alessandro Bortolami; Federico Sesti
Journal:  PLoS One       Date:  2020-10-09       Impact factor: 3.240

7.  C. elegans as an in vivo model system for the phenotypic drug discovery for treating paraquat poisoning.

Authors:  Peng Ji; Hongyuan Li; Yushan Jin; Yinghua Peng; Lihui Zhao; Xiaohui Wang
Journal:  PeerJ       Date:  2022-02-01       Impact factor: 2.984

Review 8.  The pursuit of precision mitochondrial medicine: Harnessing preclinical cellular and animal models to optimize mitochondrial disease therapeutic discovery.

Authors:  Marni J Falk
Journal:  J Inherit Metab Dis       Date:  2020-11-02       Impact factor: 4.982

Review 9.  State-of-the-Art Technology of Model Organisms for Current Human Medicine.

Authors:  Masamitsu Konno; Ayumu Asai; Toru Kitagawa; Masami Yabumoto; Ken Ofusa; Takahiro Arai; Takaaki Hirotsu; Yuichiro Doki; Hidetoshi Eguchi; Hideshi Ishii
Journal:  Diagnostics (Basel)       Date:  2020-06-10

10.  C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis.

Authors:  Giulia Faravelli; Sara Raimondi; Loredana Marchese; Frederick A Partridge; Cristina Soria; P Patrizia Mangione; Diana Canetti; Michele Perni; Francesco A Aprile; Irene Zorzoli; Elia Di Schiavi; David A Lomas; Vittorio Bellotti; David B Sattelle; Sofia Giorgetti
Journal:  Sci Rep       Date:  2019-12-27       Impact factor: 4.379
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