Literature DB >> 28136694

Sulforaphene attenuates multinucleation of pre-osteoclasts by suppressing expression of cell-cell fusion-associated genes DC-STAMP, OC-STAMP, and Atp6v0d2.

Tomohiro Takagi1, Hirofumi Inoue1, Nobuyuki Takahashi1, Rie Katsumata-Tsuboi1, Mariko Uehara1.   

Abstract

We assessed the effect of sulforaphene (SFE) on osteoclast differentiation. SFE significantly decreased the number of RANKL-induced tartrate-resistant acid phosphatase-positive cells and suppressed pre-osteoclast multinucleation. Furthermore, SFE downregulated mRNA expression of DC-STAMP, OC-STAMP, and Atp6v0d2, which encode cell-cell fusion molecules. Our data suggest that SFE attenuates pre-osteoclast multinucleation via suppression of cell-cell fusion.

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Keywords:  dendritic cell-specific transmembrane protein (DC-STAMP); isothiocyanate; osteoclast cell fusion; sulforaphene; v-ATPase V0 subunit d2(Atp6v0d2)

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Year:  2017        PMID： 28136694     DOI： 10.1080/09168451.2017.1281729

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  3 in total

1.  Erucin inhibits osteoclast formation via suppressing cell-cell fusion molecule DC-STAMP without influencing mineralization by osteoblasts.

Authors:  Tomohiro Takagi; Hirofumi Inoue; Shungo Fujii; Nobuyuki Takahashi; Mariko Uehara
Journal:  BMC Res Notes       Date:  2022-03-16

Review 2.  Osteoclast Multinucleation: Review of Current Literature.

Authors:  Joe Kodama; Takashi Kaito
Journal:  Int J Mol Sci       Date:  2020-08-08       Impact factor: 5.923

3.  Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss.

Authors:  Xiaochen Sun; Chenxi Zhang; Huan Guo; Jiao Chen; Yali Tao; Fuxiao Wang; Xixi Lin; Qian Liu; Li Su; An Qin
Journal:  Front Pharmacol       Date:  2020-03-27       Impact factor: 5.810
  3 in total

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