| Literature DB >> 28135874 |
Paula Karina S Uchoa1, Antonia T A Pimenta1, Raimundo Braz-Filho2,3, Maria da Conceição F de Oliveira1, Natália N Saraiva4, Barbara S F Rodrigues5, Ludwig H Pfenning6, Lucas M Abreu6, Diego V Wilke7, Katharine G D Florêncio7, Mary Anne S Lima1.
Abstract
A fungal strain of Aspergillus niger was recovered from sediments collected in the Northeast coast of Brazil (Pecém's offshore port terminal). Cultivation in different growth media yielded a new ester furan derivative, 1, along with malformin A1, malformin C, cyclo (trans-4-hydroxy-L-Pro-L-Leu), cyclo (trans-4-hydroxy-L-Pro-L-Phe), cyclo (L-Pro-L-Leu), cyclo (L-Pro-L-Phe), pseurotin D, pseurotin A, chlovalicin, cyclo (L-Pro-L-Tyr) and cyclo (L-Pro-L-Val). Compound 1 was cytotoxic against HCT-116 cell line, showing IC50 = 2.9 μg/mL (CI 95% from 1.8 to 4.7 μg/mL).Entities:
Keywords: Aspergillus niger; Marine-derived fungi; cytotoxic activity; furan derivative
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Year: 2017 PMID： 28135874 DOI： 10.1080/14786419.2017.1283499
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861