Guan Sun1,2, Ying Cao2, Peibei Wang3, Hongmao Song2, Tongwu Bie2, Min Li4. 1. a Department of Neurosurgery , The Forth Affiliated Hospital of Nantong Medical College , Yancheng , Jiangsu , China. 2. b Department of Ear-Nose-Throat , The Second People's Hospital of Huai'An , Jiangsu , China. 3. c Department of Ear-Nose-Throat , The Second People's Hospital of Taizhou , Taizhou , Jiangsu , China. 4. d Department of Neurosurgery , The Affiliated Jiangning Hospital of Nanjing Medical University , Nanjing , Jiangsu , China.
Abstract
CONTEXT: Circulating MicroRNAs (miRNAs) are emerging as novel biomarkers for tumour. OBJECTIVE: Evaluate the diagnostic potential of plasma miR-200b-3p in oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: miR-200b-3p was detected by qRT-PCR in paired pre-operative and post-operative plasmas from 80 OSCC patients and 80 healthy controls. RESULTS: Plasma miR-200b-3p was significantly upregulated in OSCC, and it was higher in WHO II/III grade than WHO I grade. The AUC of miR-200b-3p for OSCC was 0.9173. miR-200b-3p was significantly downregulated after surgery. High miR-200b-3p expression was associated with poor prognosis. DISCUSSION AND CONCLUSION: Plasma miR-200b-3p could be a potential diagnostic biomarker for OSCC.
CONTEXT: Circulating MicroRNAs (miRNAs) are emerging as novel biomarkers for tumour. OBJECTIVE: Evaluate the diagnostic potential of plasma miR-200b-3p in oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS:miR-200b-3p was detected by qRT-PCR in paired pre-operative and post-operative plasmas from 80 OSCC patients and 80 healthy controls. RESULTS: Plasma miR-200b-3p was significantly upregulated in OSCC, and it was higher in WHO II/III grade than WHO I grade. The AUC of miR-200b-3p for OSCC was 0.9173. miR-200b-3p was significantly downregulated after surgery. High miR-200b-3p expression was associated with poor prognosis. DISCUSSION AND CONCLUSION: Plasma miR-200b-3p could be a potential diagnostic biomarker for OSCC.
Authors: Araceli Diez-Fraile; Joke De Ceulaer; Charlotte Derpoorter; Christophe Spaas; Tom De Backer; Philippe Lamoral; Johan Abeloos; Tim Lammens Journal: Cells Date: 2020-12-31 Impact factor: 6.600
Authors: Óscar Rapado-González; Rafael López-López; José Luis López-Cedrún; Gabriel Triana-Martínez; Laura Muinelo-Romay; María Mercedes Suárez-Cunqueiro Journal: Cells Date: 2019-12-17 Impact factor: 6.600