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Literature DB >> 28135239

Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress.

Assaf Ramot^1,2, Zhiying Jiang³, Jin-Bin Tian⁴, Tali Nahum^1,2, Yael Kuperman⁵, Nicholas Justice³, Alon Chen^1,2.

Abstract

The hypothalamic-pituitary-adrenal axis is a pivotal component of an organism's response to stressful challenges, and dysfunction of this neuroendocrine axis is associated with a variety of physiological and psychological pathologies. We found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic-pituitary-adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.

Entities: Disease Gene

Mesh：

Substances：

Year: 2017 PMID： 28135239 DOI： 10.1038/nn.4491

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

21 in total

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