| Literature DB >> 28134931 |
Aleksandr B Sahakyan1,2, Pierre Murat1,2, Clemens Mayer1,2, Shankar Balasubramanian1,2,3.
Abstract
Long interspersed nuclear elements (LINEs) are ubiquitous transposable elements in higher eukaryotes that have a significant role in shaping genomes, owing to their abundance. Here we report that guanine-rich sequences in the 3' untranslated regions (UTRs) of hominoid-specific LINE-1 elements are coupled with retrotransposon speciation and contribute to retrotransposition through the formation of G-quadruplex (G4) structures. We demonstrate that stabilization of the G4 motif of a human-specific LINE-1 element by small-molecule ligands stimulates retrotransposition.Entities:
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Year: 2017 PMID： 28134931 DOI： 10.1038/nsmb.3367
Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369